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Table 1—

Clinical characteristics of patients with type 2 diabetes and HNF-1α MODY and nondiabetic control subjects

Type 2 diabetesP value (post hoc)*HNF-1α MODYP value (post hoc)*ControlP value
n 43 NA 33 NA 47 NA 
Sex (% female) 65.1 NA 75.8 NA 61.7 0.41 
Age (years) 56.2 ± 9.3 <0.0005 42.9 ± 16.1 0.68 45.5 ± 15.3 <0.0005§ 
BMI (kg/m235.1 ± 7.9 <0.0005 23.0 ± 3.4 0.13 25.5 ± 4.2 <0.0005§ 
Diabetes duration (years) 8.8, 6.0, 6.0 NA 17.3, 16.0, 12.2 NA NA 0.004 
Fasting glucose (mmol/l) 7.6, 7.5, 1.7 0.62 7.9, 7.4, 1.9 <0.00005 4.7, 4.8, 0.6 <0.00005** 
A1C (%) 7.6, 7.1, 1.4 NA 7.6, 7.7, 1.1 NA NA 0.77 
% OHA 62.8 NA 45.5 NA NA 0.13 
Creatinine (μmol/l) 70.7 ± 12.7 NA 69.2 ± 12.6 NA 69.8 ± 10.6 0.86§ 
1,5-AG (μg/ml) 11.0, 11.5, 6.7 0.003 5.9, 2.6, 4.3 <0.00005 23.9, 24.5, 4.9 <0.00005** 
Type 2 diabetesP value (post hoc)*HNF-1α MODYP value (post hoc)*ControlP value
n 43 NA 33 NA 47 NA 
Sex (% female) 65.1 NA 75.8 NA 61.7 0.41 
Age (years) 56.2 ± 9.3 <0.0005 42.9 ± 16.1 0.68 45.5 ± 15.3 <0.0005§ 
BMI (kg/m235.1 ± 7.9 <0.0005 23.0 ± 3.4 0.13 25.5 ± 4.2 <0.0005§ 
Diabetes duration (years) 8.8, 6.0, 6.0 NA 17.3, 16.0, 12.2 NA NA 0.004 
Fasting glucose (mmol/l) 7.6, 7.5, 1.7 0.62 7.9, 7.4, 1.9 <0.00005 4.7, 4.8, 0.6 <0.00005** 
A1C (%) 7.6, 7.1, 1.4 NA 7.6, 7.7, 1.1 NA NA 0.77 
% OHA 62.8 NA 45.5 NA NA 0.13 
Creatinine (μmol/l) 70.7 ± 12.7 NA 69.2 ± 12.6 NA 69.8 ± 10.6 0.86§ 
1,5-AG (μg/ml) 11.0, 11.5, 6.7 0.003 5.9, 2.6, 4.3 <0.00005 23.9, 24.5, 4.9 <0.00005** 

Data are means ± SD or mean, median, quartile deviation. % OHA is the proportion of patients treated with oral hypoglycemic agents; the rest of the subjects were insulin treated in monotherapy or in combination with OHAs. Age, BMI, and serum creatinine concentration fit into normal distribution.

*

Non–normally distributed data, for which the Kruskal-Wallis test was significant, were further analyzed with Steel's nonparametric multiple comparison test.

χ2 test.

Tukey post hoc test.

§

One-way ANOVA.

Mann-Whitney test.

Steel test.

**

Kruskal-Wallis test. NA, not applicable.

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