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Table 2—

Association between the metabolic syndrome at baseline or each of its components (in separate models and then in a single model) and risk for incident dementia over 4 years: the 3C Study, France, 1999–2004

All-cause dementiaPAlzheimer's diseasePVascular dementiaP
n 7,077  7,077  7,077  
Separate models       
    Metabolic syndrome 1.28 (0.92–1.80) 0.15 0.81 (0.50–1.31) 0.39 2.42 (1.24–4.73) 0.01 
    High blood pressure* 1.07 (0.66–1.72) 0.79 1.06 (0.58–1.92) 0.86 3.82 (0.52–27.91) 0.19 
    High waist circumference 0.86 (0.64–1.17) 0.34 0.63 (0.43–0.94) 0.02 0.82 (0.41–1.66) 0.58 
    High triglycerides 1.45 (1.05–2.00) 0.02 0.90 (0.57–1.43) 0.67 2.27 (1.16–4.42) 0.02 
    Low HDL cholesterol§ 1.22 (0.82–1.81) 0.33 0.76 (0.42–1.35) 0.34 2.06 (0.94–4.53) 0.07 
    High glycemia 1.28 (0.88–1.88) 0.20 1.04 (0.62–1.74) 0.89 1.89 (0.89–4.02) 0.10 
Variable high glycemia (split into two variables)       
    Impaired fasting glucose 0.63 (0.26–1.53) 0.30 0.79 (0.29–2.16) 0.65 0.63 (0.09–4.60) 0.64 
    Diabetes** 1.58 (1.05–2.38) 0.03 1.15 (0.64–2.05) 0.64 2.53 (1.15–5.66) 0.02 
Single model       
    High blood pressure* 1.06 (0.65–1.70) 0.83 1.10 (0.60–2.01) 0.75 3.73 (0.51–27.4) 0.20 
    High waist circumference 0.83 (0.61–1.12) 0.22 0.64 (0.43–0.95) 0.03 0.65 (0.31–1.33) 0.24 
    High triglycerides 1.42 (1.00–2.01) 0.05 1.00 (0.61–1.64) 0.998 1.98 (0.95–4.13) 0.07 
    Low HDL cholesterol§ 1.05 (0.68–1.62) 0.81 0.80 (0.43–1.48) 0.47 1.52 (0.64–3.62) 0.34 
    High glycemia 1.21 (0.82–1.80) 0.34 1.13 (0.67–1.92) 0.65 1.61 (0.74–3.50) 0.23 
All-cause dementiaPAlzheimer's diseasePVascular dementiaP
n 7,077  7,077  7,077  
Separate models       
    Metabolic syndrome 1.28 (0.92–1.80) 0.15 0.81 (0.50–1.31) 0.39 2.42 (1.24–4.73) 0.01 
    High blood pressure* 1.07 (0.66–1.72) 0.79 1.06 (0.58–1.92) 0.86 3.82 (0.52–27.91) 0.19 
    High waist circumference 0.86 (0.64–1.17) 0.34 0.63 (0.43–0.94) 0.02 0.82 (0.41–1.66) 0.58 
    High triglycerides 1.45 (1.05–2.00) 0.02 0.90 (0.57–1.43) 0.67 2.27 (1.16–4.42) 0.02 
    Low HDL cholesterol§ 1.22 (0.82–1.81) 0.33 0.76 (0.42–1.35) 0.34 2.06 (0.94–4.53) 0.07 
    High glycemia 1.28 (0.88–1.88) 0.20 1.04 (0.62–1.74) 0.89 1.89 (0.89–4.02) 0.10 
Variable high glycemia (split into two variables)       
    Impaired fasting glucose 0.63 (0.26–1.53) 0.30 0.79 (0.29–2.16) 0.65 0.63 (0.09–4.60) 0.64 
    Diabetes** 1.58 (1.05–2.38) 0.03 1.15 (0.64–2.05) 0.64 2.53 (1.15–5.66) 0.02 
Single model       
    High blood pressure* 1.06 (0.65–1.70) 0.83 1.10 (0.60–2.01) 0.75 3.73 (0.51–27.4) 0.20 
    High waist circumference 0.83 (0.61–1.12) 0.22 0.64 (0.43–0.95) 0.03 0.65 (0.31–1.33) 0.24 
    High triglycerides 1.42 (1.00–2.01) 0.05 1.00 (0.61–1.64) 0.998 1.98 (0.95–4.13) 0.07 
    Low HDL cholesterol§ 1.05 (0.68–1.62) 0.81 0.80 (0.43–1.48) 0.47 1.52 (0.64–3.62) 0.34 
    High glycemia 1.21 (0.82–1.80) 0.34 1.13 (0.67–1.92) 0.65 1.61 (0.74–3.50) 0.23 

Data are hazard ratio (95% CI). Models are adjusted by age, sex, educational level, and city center: n = 7077, without missing data. Regressions analyzed by proportional hazards models with delayed entry and age as time scale.

*

Systolic blood pressure >130 mmHg or diastolic blood pressure >85 mmHg or medication.

Waist circumference >88 cm in women or >102 cm in men.

Triglycerides ≥ 150 mg/dl.

§

HDL cholesterol <50 mg/dl in women or <40 mg/dl in men.

Fasting glycemia ≥110 mg/dl or nonfasting glycemia ≥200 mg/dl or antidiabetes medication.

Impaired fasting glucose: fasting glycemia ≥110 mg/dl without diabetes.

**

Diabetes: fasting glycemia ≥126 mg/dl or nonfasting glycemia ≥200 mg/dl or antidiabetes medication.

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