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Table 2—

Baseline characteristics and multivariate adjusted HR (95% CI) for death from stroke for subjects according to FPG and 2-h plasma glucose categories

FPG
2-h plasma glucose
Known diabetes
<6.16.1–6.9≥7.0<7.87.8–11.0≥11.1
Men        
    n (%) 8,540 (72.1) 2,043 (17.2) 537 (4.5) 9,065 (76.5) 1,558 (13.2) 497 (4.2) 724 (6.1) 
    Age (years) 56.9 ± 0.1 57.2 ± 0.3 62.4 ± 0.5 55.8 ± 0.1 63.2 ± 0.3 65.1 ± 0.5 62.8 ± 0.4 
    BMI (kg/m226.3 ± 0.0 27.4 ± 0.1 29.0 ± 0.2 26.3 ± 0.0 27.7 ± 0.1 28.9 ± 0.2 28.3 ± 0.1 
    Cholesterol (mmol/l) 6.04 ± 0.01 6.09 ± 0.03 6.11 ± 0.05 6.07 ± 0.01 5.99 ± 0.03 6.04 ± 0.05 5.78 ± 0.04 
    SBP (mmHg) 140 ± 0.2 145 ± 0.4 148 ± 0.9 140 ± 0.2 147 ± 0.5 151 ± 0.9 145 ± 0.7 
    DBP (mmHg) 83 ± 0.1 85 ± 0.3 87 ± 0.5 83 ± 0.1 86 ± 0.3 87 ± 0.5 84 ± 0.4 
    Smoking 2,507 (29.4) 637 (31.2) 157 (29.2) 2,835 (31.3) 360 (23.1) 106 (21.3) 166 (22.9) 
    Stroke        
n (%) 141 (1.7) 45 (2.2) 15 (2.8) 153 (1.7) 35 (2.2) 13 (2.6) 30 (4.1) 
n per 1,000 person-years 1.46 1.90 3.24 1.43 2.47 3.50 5.57 
HR (95% CI) 1.05 (0.74–1.49) 1.37 (0.79–2.38) 1.43 (0.97–2.11) 1.82 (1.01–3.29) 3.32 (2.16–5.12) 
Women        
    n (%) 8,169 (82.8) 969 (9.8) 252 (2.6) 7,766 (78.7) 1,281 (13.0) 343 (3.5) 472 (4.8) 
    Age (years) 54.9 ± 0.1 59.0 ± 0.3 61.1 ± 0.6 54.5 ± 0.1 59.6 ± 0.3 62.4 ± 0.5 60.8 ± 0.5 
    BMI (kg/m226.5 ± 0.1 28.6 ± 0.2 30.6 ± 0.3 26.4 ± 0.1 28.6 ± 0.1 30.0 ± 0.3 30.1 ± 0.2 
    Cholesterol (mmol/l) 6.22 ± 0.01 6.27 ± 0.04 6.32 ± 0.07 6.22 ± 0.01 6.27 ± 0.03 6.21 ± 0.06 5.86 ± 0.05 
    SBP (mmHg) 137 ± 0.2 141 ± 0.7 143 ± 1.3 137 ± 0.2 144 ± 0.6 147 ± 1.1 147 ± 1.0 
    DBP (mmHg) 80 ± 0.1 81 ± 0.4 82 ± 0.7 80 ± 0.1 83 ± 0.3 84 ± 0.6 81 ± 0.5 
    Smoking 1,650 (20.2) 237 (24.5) 67 (26.6) 1,712 (22.0) 184 (14.4) 58 (16.9) 67 (14.2) 
    Stroke        
n (%) 37 (0.5) 10 (1.0) 7 (2.8) 36 (0.5) 9 (0.7) 9 (2.6) 14 (3.0) 
n per 1,000 person-years 0.44 1.25 3.35 0.46 0.72 3.03 3.93 
HR (95% CI) 2.04 (0.99–4.21) 4.73 (2.00–11.18) 0.90 (0.43–1.90) 3.33 (1.55–7.14) 5.60 (2.86–10.96) 
Total        
    n (%) 16,709 (77.0) 3,012 (13.9) 789 (3.6) 16,831 (77.5) 2,839 (13.1) 840 (3.9) 1,196 (5.5) 
    Age (years) 56.0 ± 0.1 57.6 ± 0.2 61.8 ± 0.4 55.2 ± 0.1 61.6 ± 0.2 63.9 ± 0.4 61.9 ± 0.3 
    BMI (kg/m226.4 ± 0.0 27.9 ± 0.1 29.5 ± 0.1 26.4 ± 0.0 28.1 ± 0.1 29.3 ± 0.1 29.1 ± 0.1 
    Cholesterol (mmol/l) 6.12 ± 0.01 6.20 ± 0.02 6.20 ± 0.04 6.14 ± 0.01 6.11 ± 0.02 6.12 ± 0.04 5.83 ± 0.03 
    SBP (mmHg) 139 ± 0.2 144 ± 0.4 146 ± 0.7 138 ± 0.2 145 ± 0.4 149 ± 0.7 146 ± 0.6 
    DBP (mmHg) 82 ± 0.1 83 ± 0.2 85 ± 0.4 82 ± 0.1 85 ± 0.2 86 ± 0.4 82 ± 0.3 
    Smoking 4,157 (24.9) 874 (29.0) 224 (28.4) 4547 (27) 544 (19.2) 164 (19.5) 233 (19.5) 
    Stroke        
n (%) 178 (1.1) 55 (1.8) 22 (2.8) 189 (1.1) 44 (1.5) 22 (2.6) 44 (3.7) 
n per 1,000 person-years 0.98 1.74 3.27 1.02 1.65 3.29 4.92 
HR (95% CI) 1.19 (0.87–1.64) 1.83 (1.16–2.89) 1.30 (0.92–1.84) 2.31 (1.46–3.67) 3.85 (2.68–5.53) 
FPG
2-h plasma glucose
Known diabetes
<6.16.1–6.9≥7.0<7.87.8–11.0≥11.1
Men        
    n (%) 8,540 (72.1) 2,043 (17.2) 537 (4.5) 9,065 (76.5) 1,558 (13.2) 497 (4.2) 724 (6.1) 
    Age (years) 56.9 ± 0.1 57.2 ± 0.3 62.4 ± 0.5 55.8 ± 0.1 63.2 ± 0.3 65.1 ± 0.5 62.8 ± 0.4 
    BMI (kg/m226.3 ± 0.0 27.4 ± 0.1 29.0 ± 0.2 26.3 ± 0.0 27.7 ± 0.1 28.9 ± 0.2 28.3 ± 0.1 
    Cholesterol (mmol/l) 6.04 ± 0.01 6.09 ± 0.03 6.11 ± 0.05 6.07 ± 0.01 5.99 ± 0.03 6.04 ± 0.05 5.78 ± 0.04 
    SBP (mmHg) 140 ± 0.2 145 ± 0.4 148 ± 0.9 140 ± 0.2 147 ± 0.5 151 ± 0.9 145 ± 0.7 
    DBP (mmHg) 83 ± 0.1 85 ± 0.3 87 ± 0.5 83 ± 0.1 86 ± 0.3 87 ± 0.5 84 ± 0.4 
    Smoking 2,507 (29.4) 637 (31.2) 157 (29.2) 2,835 (31.3) 360 (23.1) 106 (21.3) 166 (22.9) 
    Stroke        
n (%) 141 (1.7) 45 (2.2) 15 (2.8) 153 (1.7) 35 (2.2) 13 (2.6) 30 (4.1) 
n per 1,000 person-years 1.46 1.90 3.24 1.43 2.47 3.50 5.57 
HR (95% CI) 1.05 (0.74–1.49) 1.37 (0.79–2.38) 1.43 (0.97–2.11) 1.82 (1.01–3.29) 3.32 (2.16–5.12) 
Women        
    n (%) 8,169 (82.8) 969 (9.8) 252 (2.6) 7,766 (78.7) 1,281 (13.0) 343 (3.5) 472 (4.8) 
    Age (years) 54.9 ± 0.1 59.0 ± 0.3 61.1 ± 0.6 54.5 ± 0.1 59.6 ± 0.3 62.4 ± 0.5 60.8 ± 0.5 
    BMI (kg/m226.5 ± 0.1 28.6 ± 0.2 30.6 ± 0.3 26.4 ± 0.1 28.6 ± 0.1 30.0 ± 0.3 30.1 ± 0.2 
    Cholesterol (mmol/l) 6.22 ± 0.01 6.27 ± 0.04 6.32 ± 0.07 6.22 ± 0.01 6.27 ± 0.03 6.21 ± 0.06 5.86 ± 0.05 
    SBP (mmHg) 137 ± 0.2 141 ± 0.7 143 ± 1.3 137 ± 0.2 144 ± 0.6 147 ± 1.1 147 ± 1.0 
    DBP (mmHg) 80 ± 0.1 81 ± 0.4 82 ± 0.7 80 ± 0.1 83 ± 0.3 84 ± 0.6 81 ± 0.5 
    Smoking 1,650 (20.2) 237 (24.5) 67 (26.6) 1,712 (22.0) 184 (14.4) 58 (16.9) 67 (14.2) 
    Stroke        
n (%) 37 (0.5) 10 (1.0) 7 (2.8) 36 (0.5) 9 (0.7) 9 (2.6) 14 (3.0) 
n per 1,000 person-years 0.44 1.25 3.35 0.46 0.72 3.03 3.93 
HR (95% CI) 2.04 (0.99–4.21) 4.73 (2.00–11.18) 0.90 (0.43–1.90) 3.33 (1.55–7.14) 5.60 (2.86–10.96) 
Total        
    n (%) 16,709 (77.0) 3,012 (13.9) 789 (3.6) 16,831 (77.5) 2,839 (13.1) 840 (3.9) 1,196 (5.5) 
    Age (years) 56.0 ± 0.1 57.6 ± 0.2 61.8 ± 0.4 55.2 ± 0.1 61.6 ± 0.2 63.9 ± 0.4 61.9 ± 0.3 
    BMI (kg/m226.4 ± 0.0 27.9 ± 0.1 29.5 ± 0.1 26.4 ± 0.0 28.1 ± 0.1 29.3 ± 0.1 29.1 ± 0.1 
    Cholesterol (mmol/l) 6.12 ± 0.01 6.20 ± 0.02 6.20 ± 0.04 6.14 ± 0.01 6.11 ± 0.02 6.12 ± 0.04 5.83 ± 0.03 
    SBP (mmHg) 139 ± 0.2 144 ± 0.4 146 ± 0.7 138 ± 0.2 145 ± 0.4 149 ± 0.7 146 ± 0.6 
    DBP (mmHg) 82 ± 0.1 83 ± 0.2 85 ± 0.4 82 ± 0.1 85 ± 0.2 86 ± 0.4 82 ± 0.3 
    Smoking 4,157 (24.9) 874 (29.0) 224 (28.4) 4547 (27) 544 (19.2) 164 (19.5) 233 (19.5) 
    Stroke        
n (%) 178 (1.1) 55 (1.8) 22 (2.8) 189 (1.1) 44 (1.5) 22 (2.6) 44 (3.7) 
n per 1,000 person-years 0.98 1.74 3.27 1.02 1.65 3.29 4.92 
HR (95% CI) 1.19 (0.87–1.64) 1.83 (1.16–2.89) 1.30 (0.92–1.84) 2.31 (1.46–3.67) 3.85 (2.68–5.53) 

Data are n (%) and means ± SE unless otherwise indicated. Data are adjusted for age, study, and sex (when men and women combined). FPG and 2-h plasma glucose criteria are in mmol/l. DBP, diastolic blood pressure; SBP, systolic blood pressure.

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