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Table 3—

Joint associations of cardiorespiratory fitness and obesity with IFG and type 2 diabetes: ACLS, 1974–2006

Fit*
Unfit*
P value§
No.No. of casesRatAdjusted RR (95% CI)No.No. of casesRatAdjusted RR (95% CI)
IFG          
    BMI          
        18.5–24.9 kg/m2 3,461 1,538 79.0 1.00 (referent) 202 95 85.4 1.03 (0.84–1.27) 0.88 
        25.0–29.9 kg/m2 3,047 1,470 100.9 1.23 (1.14–1.32) 424 203 108.2 1.26 (1.08–1.46) 0.73 
        ≥30 kg/m2 430 194 116.9 1.37 (1.18–1.60) 231 112 135.0 1.48 (1.22–1.80) 0.25 
    Waist girth          
        ≤102 cm 4,799 2,072 87.3 1.00 (referent) 262 103 86.4 0.93 (0.76–1.14) 0.42 
        >102 cm 570 282 124.6 1.35 (1.19–1.53) 205 106 149.4 1.50 (1.22–1.83) 0.10 
    % body fat          
        <25% 5,760 2,639 87.4 1.00 (referent) 435 211 100.4 1.08 (0.93–1.24) 0.33 
        ≥25% 1,178 563 101.8 1.12 (1.02–1.23) 422 199 118.2 1.21 (1.04–1.40) 0.48 
Type 2 diabetes          
    BMI          
        18.5–24.9 kg/m2 5,565 134 2.8 1.00 (referent) 346 12 4.6 1.55 (0.86–2.81) 0.30 
        25.0–29.9 kg/m2 5,787 199 4.8 1.58 (1.26–1.97) 823 32 6.7 2.10 (1.41–3.12) 0.17 
        ≥30 kg/m2 948 50 10.2 3.00 (2.13–4.23) 537 50 21.2 5.69 (4.04–8.00) <0.001 
    Waist girth          
        ≤102 cm 8,115 201 3.6 1.00 (referent) 451 17 6.8 1.77 (1.07–2.93) 0.06 
        >102 cm 1,293 67 9.6 2.38 (1.78–3.17) 467 35 18.3 4.00 (2.76–5.80) 0.01 
    % body fat          
        <25% 9,857 284 3.7 1.00 (referent) 774 32 6.9 1.78 (1.23–2.58) 0.01 
        ≥25% 2,443 99 6.1 1.53 (1.21–1.94) 932 62 13.0 2.79 (2.10–3.70) <0.001 
Fit*
Unfit*
P value§
No.No. of casesRatAdjusted RR (95% CI)No.No. of casesRatAdjusted RR (95% CI)
IFG          
    BMI          
        18.5–24.9 kg/m2 3,461 1,538 79.0 1.00 (referent) 202 95 85.4 1.03 (0.84–1.27) 0.88 
        25.0–29.9 kg/m2 3,047 1,470 100.9 1.23 (1.14–1.32) 424 203 108.2 1.26 (1.08–1.46) 0.73 
        ≥30 kg/m2 430 194 116.9 1.37 (1.18–1.60) 231 112 135.0 1.48 (1.22–1.80) 0.25 
    Waist girth          
        ≤102 cm 4,799 2,072 87.3 1.00 (referent) 262 103 86.4 0.93 (0.76–1.14) 0.42 
        >102 cm 570 282 124.6 1.35 (1.19–1.53) 205 106 149.4 1.50 (1.22–1.83) 0.10 
    % body fat          
        <25% 5,760 2,639 87.4 1.00 (referent) 435 211 100.4 1.08 (0.93–1.24) 0.33 
        ≥25% 1,178 563 101.8 1.12 (1.02–1.23) 422 199 118.2 1.21 (1.04–1.40) 0.48 
Type 2 diabetes          
    BMI          
        18.5–24.9 kg/m2 5,565 134 2.8 1.00 (referent) 346 12 4.6 1.55 (0.86–2.81) 0.30 
        25.0–29.9 kg/m2 5,787 199 4.8 1.58 (1.26–1.97) 823 32 6.7 2.10 (1.41–3.12) 0.17 
        ≥30 kg/m2 948 50 10.2 3.00 (2.13–4.23) 537 50 21.2 5.69 (4.04–8.00) <0.001 
    Waist girth          
        ≤102 cm 8,115 201 3.6 1.00 (referent) 451 17 6.8 1.77 (1.07–2.93) 0.06 
        >102 cm 1,293 67 9.6 2.38 (1.78–3.17) 467 35 18.3 4.00 (2.76–5.80) 0.01 
    % body fat          
        <25% 9,857 284 3.7 1.00 (referent) 774 32 6.9 1.78 (1.23–2.58) 0.01 
        ≥25% 2,443 99 6.1 1.53 (1.21–1.94) 932 62 13.0 2.79 (2.10–3.70) <0.001 
*

Fit (most fit 80%); unfit (least fit 20%).

Per 1,000 person-years adjusted for age and examination year.

Adjusted for age, examination year, parental diabetes, current smoking, alcohol consumption, systolic and diastolic blood pressure, total cholesterol, and baseline IFG (for type 2 diabetes).

§

P values between fit and unfit in each category of obesity measures.

Data from 5,836 men (2,563 IFG events).

Data from 10,326 men (320 type 2 diabetes events).

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