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Table 3—

Comparison of pharmacodynamic parameters between day 1 and day 4

Pharmacodynamic parametersAll Subjects
P
Day 1Day 4Difference (95%CI)
AUCGIR (mg/kg) 948 ± 98 847 ± 82 101 (−151 to 353) 0.42 
GIRmax (mg/kg/min) 6.8 ± 0.6 7.5 ± 0.7 −0.69 (−2.49 to 1.12) 0.39 
TmaxGIR (min) 97 ± 7 79 ± 5 18 (0.38 to 35) 0.03 
Time to discontinuation of exogenous glucose (min) 254 ± 9 211 ± 12 43 (12 to 74) 0.004 
Ti50 (min) 51 ± 4 38 ± 3 13 (4 to 22) 0.004 
Td50 (min) 195 ± 8 153 ± 9 42 (18 to 66) 0.0004 
Pharmacodynamic parametersAll Subjects
P
Day 1Day 4Difference (95%CI)
AUCGIR (mg/kg) 948 ± 98 847 ± 82 101 (−151 to 353) 0.42 
GIRmax (mg/kg/min) 6.8 ± 0.6 7.5 ± 0.7 −0.69 (−2.49 to 1.12) 0.39 
TmaxGIR (min) 97 ± 7 79 ± 5 18 (0.38 to 35) 0.03 
Time to discontinuation of exogenous glucose (min) 254 ± 9 211 ± 12 43 (12 to 74) 0.004 
Ti50 (min) 51 ± 4 38 ± 3 13 (4 to 22) 0.004 
Td50 (min) 195 ± 8 153 ± 9 42 (18 to 66) 0.0004 

Data are means ± SE.

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