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Table 1—

Association between circulating concentrations of IL-1Ra and incident diabetes

ModelCovariablesOdds ratio (95% CI)P
Age and sex 1.48 (1.21–1.80) 0.0001 
Age, sex, and waist circumference 1.39 (1.11–1.74) 0.0038 
Those for model 2 plus cardiovascular risk factors (cholesterol, fasting triglycerides, systolic blood pressure, smoking*, physical activity, antihypertensive medication, and lipid-lowering medication) 1.34 (1.05–1.72) 0.021 
Those for model 2 plus socioeconomic status (employment grade1.39 (1.10–1.75) 0.0059 
Those for model 2 plus proinflammatory mediators (CRP and IL-6) 1.35 (1.06–1.70) 0.013 
Those for model 2 plus fasting glycemia (fasting glucose and fasting insulin) 1.39 (1.05–1.86) 0.024 
Those for model 2 plus 2-h glucose 1.24 (0.91–1.69) 0.17 
Age, sex, waist circumference, and all covariables from models 3–6 1.43 (1.03–2.00) 0.034 
Age, sex, waist circumference, and all covariables from models 3–7 1.20 (0.84–1.71) 0.32 
ModelCovariablesOdds ratio (95% CI)P
Age and sex 1.48 (1.21–1.80) 0.0001 
Age, sex, and waist circumference 1.39 (1.11–1.74) 0.0038 
Those for model 2 plus cardiovascular risk factors (cholesterol, fasting triglycerides, systolic blood pressure, smoking*, physical activity, antihypertensive medication, and lipid-lowering medication) 1.34 (1.05–1.72) 0.021 
Those for model 2 plus socioeconomic status (employment grade1.39 (1.10–1.75) 0.0059 
Those for model 2 plus proinflammatory mediators (CRP and IL-6) 1.35 (1.06–1.70) 0.013 
Those for model 2 plus fasting glycemia (fasting glucose and fasting insulin) 1.39 (1.05–1.86) 0.024 
Those for model 2 plus 2-h glucose 1.24 (0.91–1.69) 0.17 
Age, sex, waist circumference, and all covariables from models 3–6 1.43 (1.03–2.00) 0.034 
Age, sex, waist circumference, and all covariables from models 3–7 1.20 (0.84–1.71) 0.32 

Data are odds ratio (95% CI) given for a 1-SD increase of IL-1Ra concentrations unless otherwise indicated. IL-1Ra, triglycerides, C-reactive protein (CRP), interleukin (IL)-6, and insulin entered the models as ln-transformed variables.

*

Smoking is coded in three classes (never smoked, former smoker, and current smoker).

Physical activity is coded in three classes (none/mild, moderate, and vigorous).

Employment grade is coded in six classes running from 1 (highest grade) to 6 (lowest grade).

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