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Table 1

Glucose and insulin concentrations during an OGTT following ingestion of chlorogenic acid, decaffeinated coffee, trigonelline, or placebo in 15 healthy overweight men

Glucose (mmol/l)
Insulin (pmol/l)
−30 minTime 015 min30 min60 min90 min120 minAUC (mmol/l × 120 min)−30 minTime 015 min30 min60 min90 min120 minAUC(pmol/l × 120 min)
Placebo 5.7 ± 0.2 5.6 ± 0.2 7.7 ± 0.3 8.8 ± 0.5 8.7 ± 0.7 8.1 ± 0.7 6.8 ± 0.6 962 ± 134 70.3 ± 9.9 63.3 ± 9.1 384.0 ± 48.9 572.7 ± 79.7 513.6 ± 71.0 489.5 ± 94.6 367.5 ± 98.1 54,727 ± 21,658 
Chlorogenic acid 5.5 ± 0.1 5.5 ± 0.1 7.0 ± 0.2* 8.6 ± 0.3 8.2 ± 0.6 7.4 ± 0.7 6.9 ± 0.6 912 ± 134 67.0 ± 9.6 56.7 ± 10.1* 310.7 ± 55.7* 491.2 ± 74.6 521.1 ± 101.2 480.2 ± 142.2 407.2 ± 118.0 52,285 ± 21,658 
Decaffeinated coffee 5.6 ± 0.2 5.6 ± 0.1 7.6 ± 0.2 9.2 ± 0.3 8.9 ± 0.7 7.7 ± 0.7 6.6 ± 0.7 958 ± 134 63.3 ± 9.6 65.0 ± 9.9 331.6 ± 34.4 511.9 ± 51.7 535.5 ± 73.5 463.5 ± 106.8 358.4 ± 111.9 52,324 ± 21,658 
Trigonelline 5.6 ± 0.1 5.5 ± 0.1 7.2 ± 0.2* 9.0 ± 0.3 8.7 ± 0.5 7.9 ± 0.6 6.9 ± 0.6 952 ± 134 61.6 ± 7.6 53.9 ± 9.5 267.0 ± 27.5* 501.0 ± 82.0 580.3 ± 113.6 495.6 ± 83.3 361.3 ± 91.2 53,380 ± 21,658 
Glucose (mmol/l)
Insulin (pmol/l)
−30 minTime 015 min30 min60 min90 min120 minAUC (mmol/l × 120 min)−30 minTime 015 min30 min60 min90 min120 minAUC(pmol/l × 120 min)
Placebo 5.7 ± 0.2 5.6 ± 0.2 7.7 ± 0.3 8.8 ± 0.5 8.7 ± 0.7 8.1 ± 0.7 6.8 ± 0.6 962 ± 134 70.3 ± 9.9 63.3 ± 9.1 384.0 ± 48.9 572.7 ± 79.7 513.6 ± 71.0 489.5 ± 94.6 367.5 ± 98.1 54,727 ± 21,658 
Chlorogenic acid 5.5 ± 0.1 5.5 ± 0.1 7.0 ± 0.2* 8.6 ± 0.3 8.2 ± 0.6 7.4 ± 0.7 6.9 ± 0.6 912 ± 134 67.0 ± 9.6 56.7 ± 10.1* 310.7 ± 55.7* 491.2 ± 74.6 521.1 ± 101.2 480.2 ± 142.2 407.2 ± 118.0 52,285 ± 21,658 
Decaffeinated coffee 5.6 ± 0.2 5.6 ± 0.1 7.6 ± 0.2 9.2 ± 0.3 8.9 ± 0.7 7.7 ± 0.7 6.6 ± 0.7 958 ± 134 63.3 ± 9.6 65.0 ± 9.9 331.6 ± 34.4 511.9 ± 51.7 535.5 ± 73.5 463.5 ± 106.8 358.4 ± 111.9 52,324 ± 21,658 
Trigonelline 5.6 ± 0.1 5.5 ± 0.1 7.2 ± 0.2* 9.0 ± 0.3 8.7 ± 0.5 7.9 ± 0.6 6.9 ± 0.6 952 ± 134 61.6 ± 7.6 53.9 ± 9.5 267.0 ± 27.5* 501.0 ± 82.0 580.3 ± 113.6 495.6 ± 83.3 361.3 ± 91.2 53,380 ± 21,658 

Data are means ± SE unless otherwise indicated. Baseline values are fasting concentrations and were determined right before supplement ingestion; Time 0 was half an hour after supplement ingestion and right before the start of the OGTT.

*P < 0.05 using pairedt tests compared with the placebo value. AUC, area under the curve.

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