Standardized and aligned to the DCCT/UKPDS; measurement of glucose is less well standardized

Better index of overall glycemic exposure and risk for long-term complications

Substantially less biologic variability

Substantially less preanalytic instability

No need for fasting or timed samples

Relatively unaffected by acute (e.g., stress or illness related) perturbations in glucose levels

Currently used to guide management and adjust therapy