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Table 2

Change from baseline in nitrotyrosine, skin blood flow (LDF), skin oxygen tension (So2), and pulse wave index (Aix) at 30, 60, 120, 180, and 240 min postprandial

TreatmentTime (min)Nitrotyrosine (μg/ml)LDF (AU)So2 (%)Aix (%)
HI 30 0.25 ± 0.15 −2.2 ± 2.5 −2.1 ± 1.1 −3.9 ± 1.4 
LI 30 0.09 ± 0.07 −5.0 ± 4.5 −2.4 ± 1.6 −1.1 ± 1.6 
VJ 30 −0.26 ± 0.17* 4.1 ± 2.4* 2.5 ± 2.3* −3.0 ± 2.2 
HI 60 0.22 ± 0.17 1.2 ± 3.1 −1.9 ± 1.6 −5.0 ± 1.1 
LI 60 −0.05 ± 0.16 1.9 ± 7.6 −2.5 ± 1.9 −3.5 ± 1.4 
VJ 60 −0.03 ± 0.20 7.1 ± 5.7 2.7 ± 2.4* −3.5 ± 1.8 
HI 120 0.22 ± 0.23 5.4 ± 2.2 0.4 ± 1.2 −2.6 ± 1.8 
LI 120 0.16 ± 0.18 0.5 ± 3.5 1.4 ± 1.7 −0.3 ± 1.7 
VJ 120 0.00 ± 0.22 3.1 ± 5.0 0.6 ± 2.4 −2.8 ± 1.5 
HI 180 0.06 ± −0.24 4.8 ± 2.9 0.8 ± 1.5 −0.9 ± 1.3 
LI 180 −0.06 ± 0.22 −1.2 ± 7.3 −0.6 ± 2.1 2.6 ± 1.7 
VJ 180 −0.16 ± 0.17 4.5 ± 7.6 −0.8 ± 2.2 1.6 ± 2.4 
HI 240 0.16 ± 0.24 1.1 ± 3.3 1.2 ± 1.2 −0.4 ± 1.2 
LI 240 −0.07 ± 0.23 1.4 ± 6.7 −1.2 ± 1.4 1.1 ± 1.2 
VJ 240 −0.26 ± 0.18 9.1 ± 9.4 −0.8 ± 1.8 0.8 ± 2.2 
TreatmentTime (min)Nitrotyrosine (μg/ml)LDF (AU)So2 (%)Aix (%)
HI 30 0.25 ± 0.15 −2.2 ± 2.5 −2.1 ± 1.1 −3.9 ± 1.4 
LI 30 0.09 ± 0.07 −5.0 ± 4.5 −2.4 ± 1.6 −1.1 ± 1.6 
VJ 30 −0.26 ± 0.17* 4.1 ± 2.4* 2.5 ± 2.3* −3.0 ± 2.2 
HI 60 0.22 ± 0.17 1.2 ± 3.1 −1.9 ± 1.6 −5.0 ± 1.1 
LI 60 −0.05 ± 0.16 1.9 ± 7.6 −2.5 ± 1.9 −3.5 ± 1.4 
VJ 60 −0.03 ± 0.20 7.1 ± 5.7 2.7 ± 2.4* −3.5 ± 1.8 
HI 120 0.22 ± 0.23 5.4 ± 2.2 0.4 ± 1.2 −2.6 ± 1.8 
LI 120 0.16 ± 0.18 0.5 ± 3.5 1.4 ± 1.7 −0.3 ± 1.7 
VJ 120 0.00 ± 0.22 3.1 ± 5.0 0.6 ± 2.4 −2.8 ± 1.5 
HI 180 0.06 ± −0.24 4.8 ± 2.9 0.8 ± 1.5 −0.9 ± 1.3 
LI 180 −0.06 ± 0.22 −1.2 ± 7.3 −0.6 ± 2.1 2.6 ± 1.7 
VJ 180 −0.16 ± 0.17 4.5 ± 7.6 −0.8 ± 2.2 1.6 ± 2.4 
HI 240 0.16 ± 0.24 1.1 ± 3.3 1.2 ± 1.2 −0.4 ± 1.2 
LI 240 −0.07 ± 0.23 1.4 ± 6.7 −1.2 ± 1.4 1.1 ± 1.2 
VJ 240 −0.26 ± 0.18 9.1 ± 9.4 −0.8 ± 1.8 0.8 ± 2.2 

Data are means ± SEM.

*P < 0.05 vs. human regular insulin.

P < 0.05 vs. insulin lispro. AU, arbitrary units; HI, human insulin; LI, insulin lispro; VJ, VIAject.

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