Skip to Main Content
Table 1

Glucose control and plasma insulin levels during closed-loop and control phases in eight type 1 diabetic patients treated by implanted insulin pumps and monitored by a subcutaneous glucose sensor

Whole period
Nonpostprandial period
Early postprandial period
ControlClosed-loop95% CIPControlClosed-loop95% CIPControlClosed-loop95% CIP
Blood glucose (mmol/l) 7.6 ± 0.7 7.4 ± 0.4 −1.1 to 0.5 0.401 7.9 ± 0.6 6.9 ± 0.3 −1.9 to 0.0 0.036 8.6 ± 0.9 8.8 ± 0.5 −0.9 to 1.4 0.484 
Plasma insulin (mIU/l) 20.9 ± 3.5 17.7 ± 2.2 −7.9 to 1.4 0.161 11.8 ± 2.0 15.6 ± 2.1 0.9 to 6.7 0.012 30.4 ± 5.4 21.8 ± 2.7 −16.5 to −0.6 0.050 
Time spent with blood glucose (mmol/l)             
    >10% 21.0 ± 8.0 13.6 ± 3.3 −19.0 to 4.2 0.263 18.0 ± 7.3 9.0 ± 2.6 −21.1 to 3.2 0.128 29.9 ± 11.5 27.4 ± 6.8 −20.2 to 15.2 0.866 
    >6.6% 57.0 ± 8.1 51.0 ± 4.9 −16.2 to 4.1 0.161 53.8 ± 8.4 42.0 ± 6.0 −22.2 to −1.4 0.036 66.5 ± 11.9 77.7 ± 4.2 −10.7 to 33.0 0.575 
    ≤4.4 and ≥6.6% 27.7 ± 6.2 39.1 ± 4.5 1.9 to 20.8 0.05 28.6 ± 7.4 46.3 ± 5.3 4.9 to 30.4 0.025 25.0 ± 7.0 17.7 ± 3.4 −18.7 to 4.1 0.123 
    <4.4% 15.3 ± 4.6 9.9 ± 2.7 −18.2 to 7.6 0.401 17.6 ± 5.4 11.7 ± 3.5 −21.9 to 10.2 0.779 8.5 ± 5.5 4.6 ± 1.4 −15.2 to 7.4 0.753 
    <3.3% 0.6 ± 0.5 1.6 ± 1.2 −2.3 to 4.3 0.686 0.6 ± 0.6 1.8 ± 1.4 −2.8 to 5.0 0.593 0.5 ± 0.5 1.0 ± 0.7 −1.8 to 2.8 0.593 
Whole period
Nonpostprandial period
Early postprandial period
ControlClosed-loop95% CIPControlClosed-loop95% CIPControlClosed-loop95% CIP
Blood glucose (mmol/l) 7.6 ± 0.7 7.4 ± 0.4 −1.1 to 0.5 0.401 7.9 ± 0.6 6.9 ± 0.3 −1.9 to 0.0 0.036 8.6 ± 0.9 8.8 ± 0.5 −0.9 to 1.4 0.484 
Plasma insulin (mIU/l) 20.9 ± 3.5 17.7 ± 2.2 −7.9 to 1.4 0.161 11.8 ± 2.0 15.6 ± 2.1 0.9 to 6.7 0.012 30.4 ± 5.4 21.8 ± 2.7 −16.5 to −0.6 0.050 
Time spent with blood glucose (mmol/l)             
    >10% 21.0 ± 8.0 13.6 ± 3.3 −19.0 to 4.2 0.263 18.0 ± 7.3 9.0 ± 2.6 −21.1 to 3.2 0.128 29.9 ± 11.5 27.4 ± 6.8 −20.2 to 15.2 0.866 
    >6.6% 57.0 ± 8.1 51.0 ± 4.9 −16.2 to 4.1 0.161 53.8 ± 8.4 42.0 ± 6.0 −22.2 to −1.4 0.036 66.5 ± 11.9 77.7 ± 4.2 −10.7 to 33.0 0.575 
    ≤4.4 and ≥6.6% 27.7 ± 6.2 39.1 ± 4.5 1.9 to 20.8 0.05 28.6 ± 7.4 46.3 ± 5.3 4.9 to 30.4 0.025 25.0 ± 7.0 17.7 ± 3.4 −18.7 to 4.1 0.123 
    <4.4% 15.3 ± 4.6 9.9 ± 2.7 −18.2 to 7.6 0.401 17.6 ± 5.4 11.7 ± 3.5 −21.9 to 10.2 0.779 8.5 ± 5.5 4.6 ± 1.4 −15.2 to 7.4 0.753 
    <3.3% 0.6 ± 0.5 1.6 ± 1.2 −2.3 to 4.3 0.686 0.6 ± 0.6 1.8 ± 1.4 −2.8 to 5.0 0.593 0.5 ± 0.5 1.0 ± 0.7 −1.8 to 2.8 0.593 

Data are arithmetic means ± SEM and 95% CI.

Close Modal

or Create an Account

Close Modal
Close Modal