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Table 1

Effect of glycemic control on CVD in the UKPDS and DCCT studies

Intensive (rate/100 patient-years)Conventional (rate/100 patient-years)Risk reduction (%)P
End points     
    UKPDS     
        Any diabetes related* 4.09 4.60 12 0.029 
        Myocardial infarction 1.47 1.74 16 0.052 
        Stroke 0.56 0.50 — 0.52 
    Peripheral vascular disease 0.11 0.16 — 0.15 
    DCCT     
        Cardiac 0.06 0.29 78 0.065 
        Peripheral vascular disease 0.43 0.55 22 0.16 
        Combined 0.49 0.84 42 0.082 
Intensive (rate/100 patient-years)Conventional (rate/100 patient-years)Risk reduction (%)P
End points     
    UKPDS     
        Any diabetes related* 4.09 4.60 12 0.029 
        Myocardial infarction 1.47 1.74 16 0.052 
        Stroke 0.56 0.50 — 0.52 
    Peripheral vascular disease 0.11 0.16 — 0.15 
    DCCT     
        Cardiac 0.06 0.29 78 0.065 
        Peripheral vascular disease 0.43 0.55 22 0.16 
        Combined 0.49 0.84 42 0.082 

From Refs. 19 and 24.

*Combined microvascular and macrovascular events.

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