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Table 3

NCS results at DCCT baseline, DCCT closeout, and EDIC years 13–14

Nerve/attributeDCCT baselineDCCT closeoutEDIC years 13–14
Median motor    
    Amplitude (abnormal limit <4.2) (mV)    
        INT 10.2 (4.5–17.5) 10.1 (5.0–16.0) 8.8 (4.2–14.8) 
        CONV 10.0 (4.5–17.0) 10.0 (5.0–16.0) 8.9 (4.0–14.4) 
    Conduction velocity (abnormal limit <49.0) (m/s)    
        INT 54.0 (46.5–61.2) 55.0 (48.0–61.1) 51.4 (42.5–58.2)* 
        CONV 53.8 (46.9–60.3) 52.3 (44.2–59.3) 51.0 (42.9–57.7) 
    F wave latency (abnormal limit >31.8) (ms)    
        INT 28.0 (24.0–33.0) 27.6 (24.1–32.1) 29.5 (25.4–35.0) 
        CONV 28.0 (24.0–32.6) 28.8 (24.8–34.0) 29.9 (25.6–36.4) 
Median sensory    
    Amplitude (abnormal limit <10.0) (μV)    
        INT 19.0 (7.0–47.0) 15.0 (5.0–45.0) 9.0 (0.0–29.0) 
        CONV 20.0 (7.0–50.0) 14.0 (3.0–40.0) 8.0 (0.0–29.0) 
    Conduction velocity (abnormal limit <48.0) (m/s)    
        INT 51.8 (38.2–63.4) 51.8 (36.8–62.0) 43.8 (25.9–57.9) 
        CONV 52.1 (39.4–64.0) 50.0 (33.0–61.0) 43.1 (25.9–56.8) 
Peroneal motor    
    Amplitude (abnormal limit <2.5) (mV)    
        INT 5.6 (2.0–10.0) 5.8 (2.0–10.0) 4.2 (0.3–9.0) 
        CONV 5.5 (2.0–10.9) 5.0 (1.1–10.0) 3.5 (0.1–7.6) 
    Conduction velocity (abnormal limit <40.0) (m/s)    
        INT 43.7 (35.5–51.5) 45.0 (37.0–52.0) 42.1 (30.5–49.3) 
        CONV 43.8 (35.6–50.9) 41.5 (33.0–49.0) 40.6 (25.7–47.8) 
    F wave latency (abnormal limit >56.0) (ms)    
        INT 50.4 (41.6–61.6) 50.6 (42.0–69.8) 53.3 (43.9–74.0) 
        CONV 50.8 (40.4–62.0) 54.5 (42.9–69.8) 55.5 (45.1–74.0) 
Sural sensory    
    Amplitude (abnormal limit <5.0) (μV)    
        INT 12.0 (0.0–28.0) 11.0 (0.0–27.0) 7.0 (0.0–18.0) 
        CONV 13.0 (0.0–30.0) 9.0 (0.0–23.0) 5.0 (0.0–15.0) 
Conduction velocity (abnormal limit <40.0) (m/s)    
        INT 45.1 (35.0–56.0) 45.2 (35.9–56.0) 42.4 (29.8–51.9) 
        CONV 45.2 (34.1–56.0) 42.4 (34.6–52.0) 40.0 (29.8–50.0) 
Overall (test of stochastic ordering) Z = 1.74 Z = 7.99 Z = 4.60 
 P = 0.0819 P = <0.0001 P = <0.0001 
Nerve/attributeDCCT baselineDCCT closeoutEDIC years 13–14
Median motor    
    Amplitude (abnormal limit <4.2) (mV)    
        INT 10.2 (4.5–17.5) 10.1 (5.0–16.0) 8.8 (4.2–14.8) 
        CONV 10.0 (4.5–17.0) 10.0 (5.0–16.0) 8.9 (4.0–14.4) 
    Conduction velocity (abnormal limit <49.0) (m/s)    
        INT 54.0 (46.5–61.2) 55.0 (48.0–61.1) 51.4 (42.5–58.2)* 
        CONV 53.8 (46.9–60.3) 52.3 (44.2–59.3) 51.0 (42.9–57.7) 
    F wave latency (abnormal limit >31.8) (ms)    
        INT 28.0 (24.0–33.0) 27.6 (24.1–32.1) 29.5 (25.4–35.0) 
        CONV 28.0 (24.0–32.6) 28.8 (24.8–34.0) 29.9 (25.6–36.4) 
Median sensory    
    Amplitude (abnormal limit <10.0) (μV)    
        INT 19.0 (7.0–47.0) 15.0 (5.0–45.0) 9.0 (0.0–29.0) 
        CONV 20.0 (7.0–50.0) 14.0 (3.0–40.0) 8.0 (0.0–29.0) 
    Conduction velocity (abnormal limit <48.0) (m/s)    
        INT 51.8 (38.2–63.4) 51.8 (36.8–62.0) 43.8 (25.9–57.9) 
        CONV 52.1 (39.4–64.0) 50.0 (33.0–61.0) 43.1 (25.9–56.8) 
Peroneal motor    
    Amplitude (abnormal limit <2.5) (mV)    
        INT 5.6 (2.0–10.0) 5.8 (2.0–10.0) 4.2 (0.3–9.0) 
        CONV 5.5 (2.0–10.9) 5.0 (1.1–10.0) 3.5 (0.1–7.6) 
    Conduction velocity (abnormal limit <40.0) (m/s)    
        INT 43.7 (35.5–51.5) 45.0 (37.0–52.0) 42.1 (30.5–49.3) 
        CONV 43.8 (35.6–50.9) 41.5 (33.0–49.0) 40.6 (25.7–47.8) 
    F wave latency (abnormal limit >56.0) (ms)    
        INT 50.4 (41.6–61.6) 50.6 (42.0–69.8) 53.3 (43.9–74.0) 
        CONV 50.8 (40.4–62.0) 54.5 (42.9–69.8) 55.5 (45.1–74.0) 
Sural sensory    
    Amplitude (abnormal limit <5.0) (μV)    
        INT 12.0 (0.0–28.0) 11.0 (0.0–27.0) 7.0 (0.0–18.0) 
        CONV 13.0 (0.0–30.0) 9.0 (0.0–23.0) 5.0 (0.0–15.0) 
Conduction velocity (abnormal limit <40.0) (m/s)    
        INT 45.1 (35.0–56.0) 45.2 (35.9–56.0) 42.4 (29.8–51.9) 
        CONV 45.2 (34.1–56.0) 42.4 (34.6–52.0) 40.0 (29.8–50.0) 
Overall (test of stochastic ordering) Z = 1.74 Z = 7.99 Z = 4.60 
 P = 0.0819 P = <0.0001 P = <0.0001 

Data are median (5–95%).

*P < 0.05 former intensive treatment group (INT) vs. former conventional treatment group (CONV).

P < 0.01 INT vs. CONV.

‡The test of stochastic ordering tests whether the majority of the measures show differences in a single direction, thus favoring one treatment group over the other.

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