Skip to Main Content
Table 1

Effects of COX2 inhibition and hyperglycemia in type 1 diabetes

Before COX2 inhibition
After COX2 inhibition
Hyperfiltration group
Normofiltration group
Hyperfiltration group
Normofiltration group
EuglycemiaHyperglycemiaEuglycemiaHyperglycemiaEuglycemiaHyperglycemiaEuglycemiaHyperglycemia
Biochemistry         
    Plasma insulin (pmol/l) 87 ± 51 101 ± 52 98 ± 99 88 ± 100 103 ± 69 105 ± 74 83 ± 49 77 ± 73 
Blood pressure         
    Systolic blood pressure 114 ± 10 113 ± 8 117 ± 10 116 ± 13 112 ± 10 116 ± 11 119 ± 9 120 ± 9 
    Diastolic blood pressure 65 ± 9 62 ± 5 60 ± 5 61 ± 4 62 ± 9 65 ± 7 65 ± 7 66 ± 9 
    Mean arterial pressure 83 ± 9 79 ± 6 79 ± 7 79 ± 8 79 ± 9 82 ± 8 83 ± 8 84 ± 8 
    Heart rate (bpm) 70 ± 11 68 ± 11 61 ± 13 61 ± 10 67 ± 12 64 ± 13 62 ± 11 61 ± 12 
Endothelial function         
    FMD (% change) 5.9 ± 2.3 7.6 ± 2.9 10.2 ± 5.3* 8.3 ± 4.23 8.3 ± 3.9 8.2 ± 2.54 5.8 ± 3.4 8.1 ± 3.2 
    GTN (% change) 13.0 ± 3.2 14.2 ± 3.1 11.0 ± 3.7 13.7 ± 7.9 12.1 ± 4.2 14.7 ± 4.9 11.1 ± 4.7 13.9 ± 7.0 
Before COX2 inhibition
After COX2 inhibition
Hyperfiltration group
Normofiltration group
Hyperfiltration group
Normofiltration group
EuglycemiaHyperglycemiaEuglycemiaHyperglycemiaEuglycemiaHyperglycemiaEuglycemiaHyperglycemia
Biochemistry         
    Plasma insulin (pmol/l) 87 ± 51 101 ± 52 98 ± 99 88 ± 100 103 ± 69 105 ± 74 83 ± 49 77 ± 73 
Blood pressure         
    Systolic blood pressure 114 ± 10 113 ± 8 117 ± 10 116 ± 13 112 ± 10 116 ± 11 119 ± 9 120 ± 9 
    Diastolic blood pressure 65 ± 9 62 ± 5 60 ± 5 61 ± 4 62 ± 9 65 ± 7 65 ± 7 66 ± 9 
    Mean arterial pressure 83 ± 9 79 ± 6 79 ± 7 79 ± 8 79 ± 9 82 ± 8 83 ± 8 84 ± 8 
    Heart rate (bpm) 70 ± 11 68 ± 11 61 ± 13 61 ± 10 67 ± 12 64 ± 13 62 ± 11 61 ± 12 
Endothelial function         
    FMD (% change) 5.9 ± 2.3 7.6 ± 2.9 10.2 ± 5.3* 8.3 ± 4.23 8.3 ± 3.9 8.2 ± 2.54 5.8 ± 3.4 8.1 ± 3.2 
    GTN (% change) 13.0 ± 3.2 14.2 ± 3.1 11.0 ± 3.7 13.7 ± 7.9 12.1 ± 4.2 14.7 ± 4.9 11.1 ± 4.7 13.9 ± 7.0 

Data are means ± SD. Clamped euglycemia = 4–6 mmol/l; clamped hyperglycemia = 9–11 mmol/l.

*P = 0.003 for FMD during clamped euglycemia in the hyperfiltering group vs. the normofiltering group.

P = 0.006 for the effect of COX2 inhibition on FMD in the normofiltering group during clamped euglycemia.

P = 0.003 for the change in FMD in hyperfilterers vs. normofilterers in response to COX2 inhibition during clamped euglycemia.

Close Modal

or Create an Account

Close Modal
Close Modal