Effects of COX2 inhibition and hyperglycemia in type 1 diabetes
| . | Before COX2 inhibition . | After COX2 inhibition . | ||||||
|---|---|---|---|---|---|---|---|---|
| Hyperfiltration group . | Normofiltration group . | Hyperfiltration group . | Normofiltration group . | |||||
| Euglycemia . | Hyperglycemia . | Euglycemia . | Hyperglycemia . | Euglycemia . | Hyperglycemia . | Euglycemia . | Hyperglycemia . | |
| Biochemistry | ||||||||
| Plasma insulin (pmol/l) | 87 ± 51 | 101 ± 52 | 98 ± 99 | 88 ± 100 | 103 ± 69 | 105 ± 74 | 83 ± 49 | 77 ± 73 |
| Blood pressure | ||||||||
| Systolic blood pressure | 114 ± 10 | 113 ± 8 | 117 ± 10 | 116 ± 13 | 112 ± 10 | 116 ± 11 | 119 ± 9 | 120 ± 9 |
| Diastolic blood pressure | 65 ± 9 | 62 ± 5 | 60 ± 5 | 61 ± 4 | 62 ± 9 | 65 ± 7 | 65 ± 7 | 66 ± 9 |
| Mean arterial pressure | 83 ± 9 | 79 ± 6 | 79 ± 7 | 79 ± 8 | 79 ± 9 | 82 ± 8 | 83 ± 8 | 84 ± 8 |
| Heart rate (bpm) | 70 ± 11 | 68 ± 11 | 61 ± 13 | 61 ± 10 | 67 ± 12 | 64 ± 13 | 62 ± 11 | 61 ± 12 |
| Endothelial function | ||||||||
| FMD (% change) | 5.9 ± 2.3 | 7.6 ± 2.9 | 10.2 ± 5.3* | 8.3 ± 4.23 | 8.3 ± 3.9 | 8.2 ± 2.54 | 5.8 ± 3.4†‡ | 8.1 ± 3.2 |
| GTN (% change) | 13.0 ± 3.2 | 14.2 ± 3.1 | 11.0 ± 3.7 | 13.7 ± 7.9 | 12.1 ± 4.2 | 14.7 ± 4.9 | 11.1 ± 4.7 | 13.9 ± 7.0 |
| . | Before COX2 inhibition . | After COX2 inhibition . | ||||||
|---|---|---|---|---|---|---|---|---|
| Hyperfiltration group . | Normofiltration group . | Hyperfiltration group . | Normofiltration group . | |||||
| Euglycemia . | Hyperglycemia . | Euglycemia . | Hyperglycemia . | Euglycemia . | Hyperglycemia . | Euglycemia . | Hyperglycemia . | |
| Biochemistry | ||||||||
| Plasma insulin (pmol/l) | 87 ± 51 | 101 ± 52 | 98 ± 99 | 88 ± 100 | 103 ± 69 | 105 ± 74 | 83 ± 49 | 77 ± 73 |
| Blood pressure | ||||||||
| Systolic blood pressure | 114 ± 10 | 113 ± 8 | 117 ± 10 | 116 ± 13 | 112 ± 10 | 116 ± 11 | 119 ± 9 | 120 ± 9 |
| Diastolic blood pressure | 65 ± 9 | 62 ± 5 | 60 ± 5 | 61 ± 4 | 62 ± 9 | 65 ± 7 | 65 ± 7 | 66 ± 9 |
| Mean arterial pressure | 83 ± 9 | 79 ± 6 | 79 ± 7 | 79 ± 8 | 79 ± 9 | 82 ± 8 | 83 ± 8 | 84 ± 8 |
| Heart rate (bpm) | 70 ± 11 | 68 ± 11 | 61 ± 13 | 61 ± 10 | 67 ± 12 | 64 ± 13 | 62 ± 11 | 61 ± 12 |
| Endothelial function | ||||||||
| FMD (% change) | 5.9 ± 2.3 | 7.6 ± 2.9 | 10.2 ± 5.3* | 8.3 ± 4.23 | 8.3 ± 3.9 | 8.2 ± 2.54 | 5.8 ± 3.4†‡ | 8.1 ± 3.2 |
| GTN (% change) | 13.0 ± 3.2 | 14.2 ± 3.1 | 11.0 ± 3.7 | 13.7 ± 7.9 | 12.1 ± 4.2 | 14.7 ± 4.9 | 11.1 ± 4.7 | 13.9 ± 7.0 |
Data are means ± SD. Clamped euglycemia = 4–6 mmol/l; clamped hyperglycemia = 9–11 mmol/l.
*P = 0.003 for FMD during clamped euglycemia in the hyperfiltering group vs. the normofiltering group.
†P = 0.006 for the effect of COX2 inhibition on FMD in the normofiltering group during clamped euglycemia.
‡P = 0.003 for the change in FMD in hyperfilterers vs. normofilterers in response to COX2 inhibition during clamped euglycemia.