American Diabetes Association

Table 3

DKA rates in children aged <5 years and <2 years at diagnosis

Study	Total DKA				Mild DKA				Severe DKA
Study	<2 years**	P value	<5 years**	P value	<2 years**	P value	<5 years**	P value	<2 years**	P value	<5 years**	P value
TEDDY (strict DKA definition)*	5/31	—	8/61	—	2/31	—	5/61	—	3/31	—	3/61	—
	16.1%		13.1%		6.5%		8.2%		9.7%		4.9%
	(6.1–34.5)		(6.2–24.8)		(1.1–22.8)		(3.1–18.8)		(2.5–26.9)		(1.3–14.6)
TEDDY (broad DKA definition)Ŧ	6/40	—	9/79	—	3/40	—	6/79	—	3/40	—	3/79	—
	15%		11.3%		7.5%		7.6%		7.5%		3.8%
	(6.3–30.5)		(5.7–21.0)		(2.0–21.5)		(3.1–16.4)		(2.0–21.5)		(0.9–11.5)
Sweden registry*	51/129	0.02	102/604	0.45	39/129	0.005	78/604	0.41	12/129	1	24/604	0.73
	39.5%		16.9%		30.2%		12.9%		9.3%		4.0%
	(31.2–48.6)		(14.0–20.2)		(22.6–39.0)		(10.4–15.9)		(5.1–16.0)		(2.6–5.9)
SEARCHŦ	29/58	<0.0001	100/275	<0.0001	NA	NA	NA	NA	NA	NA	NA	NA
	50.0%		36.4%
	(36.7–63.3)		(30.7–42.4)
Finland registryŦ	82/183	<0.0001	138/737	0.11	64/183	0.0005	114/737	0.06	18/183	0.77	24/737	0.74
	44.8%		18.7%		35.0%		15.5%		9.8%		3.3%
	(37.5–52.3)		(16.0–21.8)		(28.1–42.4)		(12.9–18.1)		(5.9–15.1)		(2.1–4.8)
German registryŦ	235/435	<0.0001	583/1,812	<0.0001	171/435	<0.0001	458/1,812	<0.0001	64/435	0.34	125/1,812	0.36
	54%		32.2%		39.3%		25.3%		14.7%		6.9%
	(49.2–58.8)		(30.0–34.4)		(34.7–44.1)		(23.3–27.4)		(11.6–18.5)		(5.8–8.2)

Study	Total DKA				Mild DKA				Severe DKA
Study	<2 years**	P value	<5 years**	P value	<2 years**	P value	<5 years**	P value	<2 years**	P value	<5 years**	P value
TEDDY (strict DKA definition)*	5/31	—	8/61	—	2/31	—	5/61	—	3/31	—	3/61	—
	16.1%		13.1%		6.5%		8.2%		9.7%		4.9%
	(6.1–34.5)		(6.2–24.8)		(1.1–22.8)		(3.1–18.8)		(2.5–26.9)		(1.3–14.6)
TEDDY (broad DKA definition)Ŧ	6/40	—	9/79	—	3/40	—	6/79	—	3/40	—	3/79	—
	15%		11.3%		7.5%		7.6%		7.5%		3.8%
	(6.3–30.5)		(5.7–21.0)		(2.0–21.5)		(3.1–16.4)		(2.0–21.5)		(0.9–11.5)
Sweden registry*	51/129	0.02	102/604	0.45	39/129	0.005	78/604	0.41	12/129	1	24/604	0.73
	39.5%		16.9%		30.2%		12.9%		9.3%		4.0%
	(31.2–48.6)		(14.0–20.2)		(22.6–39.0)		(10.4–15.9)		(5.1–16.0)		(2.6–5.9)
SEARCHŦ	29/58	<0.0001	100/275	<0.0001	NA	NA	NA	NA	NA	NA	NA	NA
	50.0%		36.4%
	(36.7–63.3)		(30.7–42.4)
Finland registryŦ	82/183	<0.0001	138/737	0.11	64/183	0.0005	114/737	0.06	18/183	0.77	24/737	0.74
	44.8%		18.7%		35.0%		15.5%		9.8%		3.3%
	(37.5–52.3)		(16.0–21.8)		(28.1–42.4)		(12.9–18.1)		(5.9–15.1)		(2.1–4.8)
German registryŦ	235/435	<0.0001	583/1,812	<0.0001	171/435	<0.0001	458/1,812	<0.0001	64/435	0.34	125/1,812	0.36
	54%		32.2%		39.3%		25.3%		14.7%		6.9%
	(49.2–58.8)		(30.0–34.4)		(34.7–44.1)		(23.3–27.4)		(11.6–18.5)		(5.8–8.2)

NA, data not available.

**N cases/sample population denominator, prevalence (95% confidence intervals).

*All comparisons made to TEDDY strict definition.

ŦAll comparisons made to TEDDY broad definition.