Relationship of 8-oxodG and 8-oxoGuo with all-cause and diabetes-related mortality
| Outcome . | Unadjusted hazard ratio (95% CI) . | P . | Age- and sex-adjusted hazard ratio (95% CI) . | P . | Multivariate-adjusted hazard ratio (95% CI)* . | P . |
|---|---|---|---|---|---|---|
| All-cause mortality | ||||||
| 8-oxodG | ||||||
| 1st Quartile | 1.0 | 1.0 | 1.0 | |||
| 2nd Quartile | 0.99 (0.83–1.19) | 0.93 | 0.88 (0.73–1.07) | 0.20 | 1.00 (0.78–1.28) | 0.98 |
| 3rd Quartile | 0.95 (0.79–1.14) | 0.60 | 0.81 (0.67–1.97) | 0.03 | 0.91 (0.71–1.15) | 0.41 |
| 4th Quartile | 1.35 (1.13–1.61) | 0.001 | 1.00 (0.83–1.20) | 0.99 | 1.07 (0.84–1.37) | 0.58 |
| Log 8-oxodG | 1.30 (1.11–1.51) | 0.001 | 1.12 (0.87–1.19) | 0.82 | 1.01 (0.82–1.25) | 0.91 |
| 8-oxoGuo | ||||||
| 1st Quartile | 1.0 | 1.0 | 1.0 | |||
| 2nd Quartile | 1.01 (0.84–1.23) | 0.88 | 0.89 (0.73–1.08) | 0.23 | 0.96 (0.74–1.23) | 0.73 |
| 3rd Quartile | 1.37 (1.14–1.65) | <0.001 | 0.95 (0.79–1.15) | 0.61 | 1.04 (0.81–1.33) | 0.77 |
| 4th Quartile | 2.05 (1.71–2.45) | <0.001 | 1.44 (1.19–1.74) | <0.001 | 1.44 (1.12–1.85) | 0.004 |
| Log 8-oxoGuo | 1.97 (1.70–2.28) | <0.001 | 1.40 (1.19–1.65) | <0.001 | 1.33 (1.07–1.64) | 0.009 |
| Diabetes-related mortality | ||||||
| 8-oxodG | ||||||
| 1st Quartile | 1.0 | 1.0 | 1.0 | |||
| 2nd Quartile | 0.99 (0.79–1.26) | 0.97 | 0.88 (0.69–1.11) | 0.28 | 1.08 (0.79–1.74) | 0.63 |
| 3rd Quartile | 0.95 (0.75–1.20) | 0.68 | 0.78 (0.61–0.98) | 0.04 | 0.99 (0.74–1.34) | 0.97 |
| 4th Quartile | 1.32 (1.05–1.66) | 0.02 | 0.98 (0.77–1.23) | 0.83 | 1.21 (0.89–1.65) | 0.22 |
| Log 8-oxodG | 1.25 (1.03–1.53) | 0.03 | 0.97 (0.79–1.18) | 0.73 | 1.10 (0.85–1.42) | 0.49 |
| 8-oxoGuo | ||||||
| 1st Quartile | 1.0 | 1.0 | 1.0 | |||
| 2nd Quartile | 0.99 (0.77–1.28) | 0.96 | 0.89 (0.69–1.14) | 0.36 | 1.03 (0.74–1.39) | 0.94 |
| 3rd Quartile | 1.36 (1.07–1.73) | 0.01 | 0.92 (0.72–1.17) | 0.50 | 1.00 (0.73–1.36) | 0.99 |
| 4th Quartile | 2.13 (1.69–2.69) | <0.001 | 1.50 (1.18–1.91) | <0.001 | 1.54 (1.13–2.10) | 0.006 |
| Log 8-oxoGuo | 2.03 (1.69–2.45) | <0.001 | 1.48 (1.21–1.82) | <0.001 | 1.40 (1.08–1.81) | 0.01 |
| Outcome . | Unadjusted hazard ratio (95% CI) . | P . | Age- and sex-adjusted hazard ratio (95% CI) . | P . | Multivariate-adjusted hazard ratio (95% CI)* . | P . |
|---|---|---|---|---|---|---|
| All-cause mortality | ||||||
| 8-oxodG | ||||||
| 1st Quartile | 1.0 | 1.0 | 1.0 | |||
| 2nd Quartile | 0.99 (0.83–1.19) | 0.93 | 0.88 (0.73–1.07) | 0.20 | 1.00 (0.78–1.28) | 0.98 |
| 3rd Quartile | 0.95 (0.79–1.14) | 0.60 | 0.81 (0.67–1.97) | 0.03 | 0.91 (0.71–1.15) | 0.41 |
| 4th Quartile | 1.35 (1.13–1.61) | 0.001 | 1.00 (0.83–1.20) | 0.99 | 1.07 (0.84–1.37) | 0.58 |
| Log 8-oxodG | 1.30 (1.11–1.51) | 0.001 | 1.12 (0.87–1.19) | 0.82 | 1.01 (0.82–1.25) | 0.91 |
| 8-oxoGuo | ||||||
| 1st Quartile | 1.0 | 1.0 | 1.0 | |||
| 2nd Quartile | 1.01 (0.84–1.23) | 0.88 | 0.89 (0.73–1.08) | 0.23 | 0.96 (0.74–1.23) | 0.73 |
| 3rd Quartile | 1.37 (1.14–1.65) | <0.001 | 0.95 (0.79–1.15) | 0.61 | 1.04 (0.81–1.33) | 0.77 |
| 4th Quartile | 2.05 (1.71–2.45) | <0.001 | 1.44 (1.19–1.74) | <0.001 | 1.44 (1.12–1.85) | 0.004 |
| Log 8-oxoGuo | 1.97 (1.70–2.28) | <0.001 | 1.40 (1.19–1.65) | <0.001 | 1.33 (1.07–1.64) | 0.009 |
| Diabetes-related mortality | ||||||
| 8-oxodG | ||||||
| 1st Quartile | 1.0 | 1.0 | 1.0 | |||
| 2nd Quartile | 0.99 (0.79–1.26) | 0.97 | 0.88 (0.69–1.11) | 0.28 | 1.08 (0.79–1.74) | 0.63 |
| 3rd Quartile | 0.95 (0.75–1.20) | 0.68 | 0.78 (0.61–0.98) | 0.04 | 0.99 (0.74–1.34) | 0.97 |
| 4th Quartile | 1.32 (1.05–1.66) | 0.02 | 0.98 (0.77–1.23) | 0.83 | 1.21 (0.89–1.65) | 0.22 |
| Log 8-oxodG | 1.25 (1.03–1.53) | 0.03 | 0.97 (0.79–1.18) | 0.73 | 1.10 (0.85–1.42) | 0.49 |
| 8-oxoGuo | ||||||
| 1st Quartile | 1.0 | 1.0 | 1.0 | |||
| 2nd Quartile | 0.99 (0.77–1.28) | 0.96 | 0.89 (0.69–1.14) | 0.36 | 1.03 (0.74–1.39) | 0.94 |
| 3rd Quartile | 1.36 (1.07–1.73) | 0.01 | 0.92 (0.72–1.17) | 0.50 | 1.00 (0.73–1.36) | 0.99 |
| 4th Quartile | 2.13 (1.69–2.69) | <0.001 | 1.50 (1.18–1.91) | <0.001 | 1.54 (1.13–2.10) | 0.006 |
| Log 8-oxoGuo | 2.03 (1.69–2.45) | <0.001 | 1.48 (1.21–1.82) | <0.001 | 1.40 (1.08–1.81) | 0.01 |
*Covariates included in the multivariate model were age, sex, smoking status, cohabitation status, physical activity, education, BMI, presence or absence of hypertension and of microalbuminuria (urinary albumin ≥15 mg/L), glycated hemoglobin, total cholesterol, triglycerides, serum creatinine, presence or absence of retinopathy and of peripheral neuropathy, and history of acute myocardial infarction and stroke.