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Table 2

AUC (95%CI) for A1C for the detection of glucose-based definitions of diabetes: ARIC study and NHANES III Second Exam participants, adults without a history of diagnosed diabetes at baseline

Diabetes definition descriptionARIC study (n = 12, 485)
NHANES III (n = 691)
n (cases)AUC (95% CI)n (cases)AUC (95% CI)
Prevalent diabetes      
    Definition 1 Fasting glucose ≥126 mg/dl at the baseline examination 840 0.892 (0.878–0.905) 29 0.938 (0.881–0.995) 
    Definition 2 Fasting glucose ≥126 mg/dl at two separate visits* 234 0.936 (0.920–0.952) 21 0.921 (0.843–0.999) 
Incident diabetes      
    Definition A Visit-detected incident diabetes (fasting glucose ≥126, medication use, or self-report) during 6 years of follow-up 1,308 0.827 (0.813–0.840) — — 
    Definition B Interview-detected diagnosed diabetes during 15 years of follow-up 2,614 0.733 (0.722–0.745) — — 
     Years 0–6 456 0.826 (0.800–0.851) — — 
     Years 6–12 1,376 0.669 (0.646–0.691) — — 
     Years 12–15 782 0.628 (0.607–0.648) — — 
Diabetes definition descriptionARIC study (n = 12, 485)
NHANES III (n = 691)
n (cases)AUC (95% CI)n (cases)AUC (95% CI)
Prevalent diabetes      
    Definition 1 Fasting glucose ≥126 mg/dl at the baseline examination 840 0.892 (0.878–0.905) 29 0.938 (0.881–0.995) 
    Definition 2 Fasting glucose ≥126 mg/dl at two separate visits* 234 0.936 (0.920–0.952) 21 0.921 (0.843–0.999) 
Incident diabetes      
    Definition A Visit-detected incident diabetes (fasting glucose ≥126, medication use, or self-report) during 6 years of follow-up 1,308 0.827 (0.813–0.840) — — 
    Definition B Interview-detected diagnosed diabetes during 15 years of follow-up 2,614 0.733 (0.722–0.745) — — 
     Years 0–6 456 0.826 (0.800–0.851) — — 
     Years 6–12 1,376 0.669 (0.646–0.691) — — 
     Years 12–15 782 0.628 (0.607–0.648) — — 

*In the ARIC study, the second examination took place 3 years after the baseline examination. In the NHANES III study population, the second examination took place ∼17 days after the baseline examination.

n = 12,060 after exclusion of individuals with fasting glucose ≥126 mg/dl at baseline or missing glucose measurements during follow-up.

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