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Table 2

Changes in CVD risk factors and association with percentage weight change for the Look AHEAD cohort

Baseline
Change from baseline to year 1
Spearman correlation of association with percentage weight loss
nMean ± SDnMean ± SDTotal cohortILI subjectsDSE subjects
Weight (kg) 5,145 100.71 ± 19.26 4,899 −4.77 ± 7.57*    
SBP (mmHg) 5,082 128.84 ± 17.17 4,837 −4.76 ± 17.05* 0.20* 0.19* 0.14* 
DBP (mmHg) 5,082 70.15 ± 9.57 4,837 −2.40 ± 8.62* 0.12* 0.13* 0.08* 
Glucose 4,999 153.19 ± 45.66 4,603 −14.32 ± 46.08* 0.27* 0.21* 0.14* 
HbA1c (%) 4,999 7.28 ± 1.17 4,606 −0.39 ± 1.02* 0.34* 0.24* 0.16* 
HDL cholesterol (mg/dL) 4,999 43.48 ± 11.83 4,603 2.39 ± 6.97* −0.23* −0.26* −0.08* 
LDL cholesterol (mg/dL) 4,998 112.31 ± 32.24 4,602 −5.47 ± 28.63* −0.004 0.0008 −0.02 
Trigylcerides (mg/dL) 4,999 153 (108–219) 4,603 −12.0 (−52 to 21)* 0.26* 0.31* 0.16* 
Baseline
Change from baseline to year 1
Spearman correlation of association with percentage weight loss
nMean ± SDnMean ± SDTotal cohortILI subjectsDSE subjects
Weight (kg) 5,145 100.71 ± 19.26 4,899 −4.77 ± 7.57*    
SBP (mmHg) 5,082 128.84 ± 17.17 4,837 −4.76 ± 17.05* 0.20* 0.19* 0.14* 
DBP (mmHg) 5,082 70.15 ± 9.57 4,837 −2.40 ± 8.62* 0.12* 0.13* 0.08* 
Glucose 4,999 153.19 ± 45.66 4,603 −14.32 ± 46.08* 0.27* 0.21* 0.14* 
HbA1c (%) 4,999 7.28 ± 1.17 4,606 −0.39 ± 1.02* 0.34* 0.24* 0.16* 
HDL cholesterol (mg/dL) 4,999 43.48 ± 11.83 4,603 2.39 ± 6.97* −0.23* −0.26* −0.08* 
LDL cholesterol (mg/dL) 4,998 112.31 ± 32.24 4,602 −5.47 ± 28.63* −0.004 0.0008 −0.02 
Trigylcerides (mg/dL) 4,999 153 (108–219) 4,603 −12.0 (−52 to 21)* 0.26* 0.31* 0.16* 

*P < 0.0001.

†For change in triglycerides, data are median (interquartile range). The signed-rank test was used to test whether the change from baseline to year 1 was different from 0.

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