American Diabetes Association

Table 3

Incidence rates of LA in metformin-treated patients stratified by CKD stage

Subgroup	Patients	LA events	Person-years	Incidence rate per  1,000 person-years (95% CI)
All patients	77,601	35	337,590.2	10.37 (7.22–14.42)
Kidney function
Normal	6,038	2	26,266.0	7.61 (0.92–27.51)
Mildly reduced	38,836	8	172,354.4	4.64 (2.00–9.15)
Moderately reduced	31,278	23	133,841.8	17.18 (10.89–25.79)
Severely reduced	1,449	2	5,127.9	39.00 (4.72–140.89)

Subgroup	Patients	LA events	Person-years	Incidence rate per  1,000 person-years (95% CI)
All patients	77,601	35	337,590.2	10.37 (7.22–14.42)
Kidney function
Normal	6,038	2	26,266.0	7.61 (0.92–27.51)
Mildly reduced	38,836	8	172,354.4	4.64 (2.00–9.15)
Moderately reduced	31,278	23	133,841.8	17.18 (10.89–25.79)
Severely reduced	1,449	2	5,127.9	39.00 (4.72–140.89)