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Table 2

HRs (95% CI) and P values for CV mortality based on updated, average insulin dose (per 1 unit/kg) from Cox proportional hazards models

Insulin categoriesUnadjustedModel 1Model 2Model 3Model 4
Total insulin 1.83 (1.45, 2.31) <0.001 1.21 (0.92, 1.60) 0.173 1.21 (0.91, 1.61) 0.191 1.12 (0.84, 1.49) 0.454 0.99 (0.74, 1.34) 0.969 
Basal insulin 2.29 (1.62, 3.23) <0.001 1.30 (0.87, 1.94) 0.207 1.29 (0.85, 1.95) 0.227 1.13 (0.74, 1.72) 0.564 0.94 (0.61, 1.46) 0.796 
Bolus insulin 3.36 (2.00, 5.66) <0.001 1.65 (0.88, 3.11) 0.117 1.63 (0.85, 3.12) 0.140 1.48 (0.77, 2.84) 0.237 1.23 (0.63, 2.40) 0.548 
Insulin categoriesUnadjustedModel 1Model 2Model 3Model 4
Total insulin 1.83 (1.45, 2.31) <0.001 1.21 (0.92, 1.60) 0.173 1.21 (0.91, 1.61) 0.191 1.12 (0.84, 1.49) 0.454 0.99 (0.74, 1.34) 0.969 
Basal insulin 2.29 (1.62, 3.23) <0.001 1.30 (0.87, 1.94) 0.207 1.29 (0.85, 1.95) 0.227 1.13 (0.74, 1.72) 0.564 0.94 (0.61, 1.46) 0.796 
Bolus insulin 3.36 (2.00, 5.66) <0.001 1.65 (0.88, 3.11) 0.117 1.63 (0.85, 3.12) 0.140 1.48 (0.77, 2.84) 0.237 1.23 (0.63, 2.40) 0.548 

Model 1 adjusted for age, history of CV disease, heart failure, amputation, education, angiotensin receptor blockers, peripheral neuropathy, Q-T index, baseline A1C, HDL, serum creatinine, urinary albumin-to-creatinine ratio, integrated health plan, and certified diabetes educator on staff at randomization. Model 2 adds assignment to blood pressure or lipid trial and treatment assignment within these, severe hypoglycemia, and weight change. Model 3 adds updated, average A1C. Model 4 adds glycemic treatment strategy assignment.

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