Table 1

Recommendations of the International Hypoglycaemia Study Group

People with diabetes treated with a sulfonylurea, a glinide, or insulin should
 • Be educated about hypoglycemia. 
 • Treat SMPG levels ≤70 mg/dL (3.9 mmol/L) to avoid progression to clinical iatrogenic hypoglycemia. 
 • Regularly be queried about hypoglycemia, including the glucose level at which symptoms develop. Those developing symptoms at a glucose level <55 mg/dL (3.0 mmol/L) should be considered at risk. 
When hypoglycemia becomes a problem, the diabetes health-care provider should 
 • Consider each conventional risk factor and those indicative of compromised glucose counterregulation. 
 • Avoid sulfonylureas (and glinides) if possible, using insulin analogs when insulin is required, and consider using CSII, CGM, and CSII + CGM in selected patients. 
 • Provide structured education and, in patients with impaired awareness of hypoglycemia, prescribe short-term scrupulous avoidance of hypoglycemia. 
 • Seek to achieve the lowest A1C level that does not cause severe hypoglycemia and preserves awareness of hypoglycemia with an acceptable number of less-than-severe episodes of hypoglycemia, provided that benefit from glycemic control can be anticipated. 
People with diabetes treated with a sulfonylurea, a glinide, or insulin should
 • Be educated about hypoglycemia. 
 • Treat SMPG levels ≤70 mg/dL (3.9 mmol/L) to avoid progression to clinical iatrogenic hypoglycemia. 
 • Regularly be queried about hypoglycemia, including the glucose level at which symptoms develop. Those developing symptoms at a glucose level <55 mg/dL (3.0 mmol/L) should be considered at risk. 
When hypoglycemia becomes a problem, the diabetes health-care provider should 
 • Consider each conventional risk factor and those indicative of compromised glucose counterregulation. 
 • Avoid sulfonylureas (and glinides) if possible, using insulin analogs when insulin is required, and consider using CSII, CGM, and CSII + CGM in selected patients. 
 • Provide structured education and, in patients with impaired awareness of hypoglycemia, prescribe short-term scrupulous avoidance of hypoglycemia. 
 • Seek to achieve the lowest A1C level that does not cause severe hypoglycemia and preserves awareness of hypoglycemia with an acceptable number of less-than-severe episodes of hypoglycemia, provided that benefit from glycemic control can be anticipated. 
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