Relationship between HDL-c and cardiovascular events and mortality in quartiles of HDL-c
| . | Quartile 1, n = 466 . | Quartile 2, n = 471 . | Quartile 3, n = 437 . | Quartile 4, n = 436 . |
|---|---|---|---|---|
| HDL-c range, mmol/L | ||||
| Men | 0.41–0.88 | 0.88–1.04 | 1.04–1.22 | 1.22–2.85 |
| Women | 0.46–1.02 | 1.02–1.20 | 1.20–1.45 | 1.45–3.00 |
| MI | ||||
| n | 28 | 40 | 35 | 12 |
| Model I | 2.39 (1.21–4.71) | 3.55 (1.86–6.76) | 3.02 (1.45–5.43) | 1.00 (ref.) |
| Model II | 2.02 (0.99–4.13) | 3.29 (1.70–6.36) | 2.75 (1.42–5.34) | 1.00 (ref.) |
| Model III | 2.02 (0.99–4.15) | 3.25 (1.67–6.30) | 2.82 (1.45–5.49) | 1.00 (ref.) |
| Ischemic stroke | ||||
| n | 24 | 17 | 18 | 12 |
| Model I | 2.04 (1.02–4.10) | 1.46 (0.70–3.05) | 1.51 (0.73–3.13) | 1.00 (ref.) |
| Model II | 1.90 (0.90–4.04) | 1.36 (0.64–2.90) | 1.39 (0.66–2.91) | 1.00 (ref.) |
| Model III | 1.82 (0.86–3.87) | 1.23 (0.57–2.63) | 1.31 (0.62–2.76) | 1.00 (ref.) |
| Vascular mortality | ||||
| n | 55 | 67 | 43 | 49 |
| Model I | 1.21 (0.82–1.79) | 1.48 (1.02–2.15) | 0.89 (0.59–1.35) | 1.00 (ref.) |
| Model II | 1.01 (0.66–1.55) | 1.32 (0.90–1.95) | 0.79 (0.52–1.20) | 1.00 (ref.) |
| Model III | 0.98 (0.64–1.50) | 1.21 (0.82–1.78) | 0.76 (0.50–1.16) | 1.00 (ref.) |
| Composite of major vascular events | ||||
| n | 89 | 97 | 84 | 65 |
| Model I | 1.50 (1.09–2.08) | 1.66 (1.21–2.27) | 1.38 (1.00–1.92) | 1.00 (ref.) |
| Model II | 1.31 (0.92–1.85) | 1.53 (1.10–2.12) | 1.26 (0.91–1.76) | 1.00 (ref.) |
| Model III | 1.28 (0.90–1.82) | 1.46 (1.05–2.02) | 1.24 (0.89–1.73) | 1.00 (ref.) |
| All-cause mortality | ||||
| n | 102 | 109 | 87 | 87 |
| Model I | 1.21 (0.90–1.61) | 1.35 (1.02–1.79) | 1.01 (0.75–1.36) | 1.00 (ref.) |
| Model II | 1.03 (0.75–1.41) | 1.21 (0.90–1.63) | 0.90 (0.66–1.22) | 1.00 (ref.) |
| Model III | 1.01 (0.74–1.39) | 1.12 (0.83–1.50) | 0.87 (0.64–1.18) | 1.00 (ref.) |
| . | Quartile 1, n = 466 . | Quartile 2, n = 471 . | Quartile 3, n = 437 . | Quartile 4, n = 436 . |
|---|---|---|---|---|
| HDL-c range, mmol/L | ||||
| Men | 0.41–0.88 | 0.88–1.04 | 1.04–1.22 | 1.22–2.85 |
| Women | 0.46–1.02 | 1.02–1.20 | 1.20–1.45 | 1.45–3.00 |
| MI | ||||
| n | 28 | 40 | 35 | 12 |
| Model I | 2.39 (1.21–4.71) | 3.55 (1.86–6.76) | 3.02 (1.45–5.43) | 1.00 (ref.) |
| Model II | 2.02 (0.99–4.13) | 3.29 (1.70–6.36) | 2.75 (1.42–5.34) | 1.00 (ref.) |
| Model III | 2.02 (0.99–4.15) | 3.25 (1.67–6.30) | 2.82 (1.45–5.49) | 1.00 (ref.) |
| Ischemic stroke | ||||
| n | 24 | 17 | 18 | 12 |
| Model I | 2.04 (1.02–4.10) | 1.46 (0.70–3.05) | 1.51 (0.73–3.13) | 1.00 (ref.) |
| Model II | 1.90 (0.90–4.04) | 1.36 (0.64–2.90) | 1.39 (0.66–2.91) | 1.00 (ref.) |
| Model III | 1.82 (0.86–3.87) | 1.23 (0.57–2.63) | 1.31 (0.62–2.76) | 1.00 (ref.) |
| Vascular mortality | ||||
| n | 55 | 67 | 43 | 49 |
| Model I | 1.21 (0.82–1.79) | 1.48 (1.02–2.15) | 0.89 (0.59–1.35) | 1.00 (ref.) |
| Model II | 1.01 (0.66–1.55) | 1.32 (0.90–1.95) | 0.79 (0.52–1.20) | 1.00 (ref.) |
| Model III | 0.98 (0.64–1.50) | 1.21 (0.82–1.78) | 0.76 (0.50–1.16) | 1.00 (ref.) |
| Composite of major vascular events | ||||
| n | 89 | 97 | 84 | 65 |
| Model I | 1.50 (1.09–2.08) | 1.66 (1.21–2.27) | 1.38 (1.00–1.92) | 1.00 (ref.) |
| Model II | 1.31 (0.92–1.85) | 1.53 (1.10–2.12) | 1.26 (0.91–1.76) | 1.00 (ref.) |
| Model III | 1.28 (0.90–1.82) | 1.46 (1.05–2.02) | 1.24 (0.89–1.73) | 1.00 (ref.) |
| All-cause mortality | ||||
| n | 102 | 109 | 87 | 87 |
| Model I | 1.21 (0.90–1.61) | 1.35 (1.02–1.79) | 1.01 (0.75–1.36) | 1.00 (ref.) |
| Model II | 1.03 (0.75–1.41) | 1.21 (0.90–1.63) | 0.90 (0.66–1.22) | 1.00 (ref.) |
| Model III | 1.01 (0.74–1.39) | 1.12 (0.83–1.50) | 0.87 (0.64–1.18) | 1.00 (ref.) |
HDL-c per quartiles. Quartile 4 = reference (ref.). Data are HR (95% CI). Model 1: age plus sex. Model 2: model 1 adjustments plus BMI, smoking, pack-years, alcohol, LDL-c, TGs, and systolic blood pressure. Model 3: model 2 adjustments plus estimated glomerular filtration rate, glucose, and HbA1c. Boldface data indicate statistically significant values, P < 0.05.