Table 3

HRs of A1C TIR predicting mortality and CVD

Cox proportional hazards modelHR95% CIP value
Mortality (n = 402,043)    
 Individual A1C TIR (reference 80–100%, n = 36,642)    
  60 to <80% (n = 41,042) 1.10 1.07–1.12 <0.001 
  40 to <60% (n = 51,609) 1.11 1.09–1.14 <0.001 
  20 to <40% (n = 76,801) 1.14 1.12–1.16 <0.001 
  0 to <20% (n = 195,949) 1.22 1.20–1.25 <0.001 
 A1C SD during baseline 1.14 1.13–1.16 <0.001 
 A1C average during baseline 1.04 1.03–1.05 <0.001 
Myocardial infarction and stroke (n = 388,515)    
 Individual A1C TIR (reference 80–100%, n = 36,309)    
  60 to <80% (n = 40,181) 1.06 1.02–1.10 <0.001 
  40 to <60% (n = 50,015) 1.07 1.04–1.11 <0.001 
  20 to <40% (n = 73,980) 1.08 1.04–1.11 <0.001 
  0 to <20% (n = 188,030) 1.14 1.11–1.19 <0.001 
 A1C SD during baseline 1.03 1.01–1.05 <0.001 
 A1C average during baseline 1.12 1.11–1.13 <0.001 
Cox proportional hazards modelHR95% CIP value
Mortality (n = 402,043)    
 Individual A1C TIR (reference 80–100%, n = 36,642)    
  60 to <80% (n = 41,042) 1.10 1.07–1.12 <0.001 
  40 to <60% (n = 51,609) 1.11 1.09–1.14 <0.001 
  20 to <40% (n = 76,801) 1.14 1.12–1.16 <0.001 
  0 to <20% (n = 195,949) 1.22 1.20–1.25 <0.001 
 A1C SD during baseline 1.14 1.13–1.16 <0.001 
 A1C average during baseline 1.04 1.03–1.05 <0.001 
Myocardial infarction and stroke (n = 388,515)    
 Individual A1C TIR (reference 80–100%, n = 36,309)    
  60 to <80% (n = 40,181) 1.06 1.02–1.10 <0.001 
  40 to <60% (n = 50,015) 1.07 1.04–1.11 <0.001 
  20 to <40% (n = 73,980) 1.08 1.04–1.11 <0.001 
  0 to <20% (n = 188,030) 1.14 1.11–1.19 <0.001 
 A1C SD during baseline 1.03 1.01–1.05 <0.001 
 A1C average during baseline 1.12 1.11–1.13 <0.001 

Model also includes all covariates listed in Supplementary Appendix D when predicting the outcomes.

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