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Table 1 —

Clinical profiles of type 2 diabetic subjects with various stages of nephropathy

ControlAll patients with diabetesStages of diabetic nephropathy
Stage 1Stage 2Stage 3Stage 4
n 54 (28/26) 75 (46/29) 39 17 10 
Age (years) 53.8 ± 1.4 56.0 ± 1.1 54.6 ± 1.7 53.9 ± 2.2 57.0 ± 2.4 64.0 ± 1.3 
BMI (kg/m222.0 ± 0.3 22.4 ± 0.3 22.2 ± 0.6 22.8 ± 0.7 22.4 ± 0.9 22.8 ± 0.6 
Duration of diabetes (years) — 11.1 ± 1.0 8.9 ± 1.1 8.1 ± 1.3 15.9 ± 2.3 20.4 ± 4.2†† 
Smoking index (cigarette-years) 183 ± 43 417 ± 59* 472 ± 88 466 ± 112 289 ± 192 230 ± 117 
Systolic blood pressure (mmHg) 122 ± 3 135 ± 3** 120 ± 2 137 ± 6 159 ± 7††† 165 ± 8††† 
Diastolic blood pressure (mmHg) 77 ± 2 73 ± 1 70 ± 1 76 ± 3 81 ± 3 76 ± 6 
HbA1c (%) — 8.7 ± 0.3 9.2 ± 0.4 8.5 ± 0.4 8.6 ± 0.8 7.0 ± 0.4 
Creatinine (μmol/l) 72 ± 2 113 ± 17 59 ± 2 68 ± 4 90 ± 16 416 ± 68††† 
Log vitamin B12 (pmol/l) — 2.76 ± 0.02 2.78 ± 0.03 2.65 ± 0.04 2.79 ± 0.05 2.82 ± 0.08 
Log folate (nmol/l) — 1.20 ± 0.02 1.20 ± 0.03 1.16 ± 0.03 1.22 ± 0.06 1.22 ± 0.05 
tHcy (μmol/l) 8.7 ± 0.3 12.0 ± 0.7*** 9.6 ± 0.4 11.2 ± 1.1 13.3 ± 1.8 21.6 ± 2.0 
Log tHcy (μmol/l) 0.920 ± 0.016 1.040 ± 0.02*** 0.966 ± 0.018 1.017 ± 0.044 1.092 ± 0.060* 1.319 ± 0.040***††† 
ControlAll patients with diabetesStages of diabetic nephropathy
Stage 1Stage 2Stage 3Stage 4
n 54 (28/26) 75 (46/29) 39 17 10 
Age (years) 53.8 ± 1.4 56.0 ± 1.1 54.6 ± 1.7 53.9 ± 2.2 57.0 ± 2.4 64.0 ± 1.3 
BMI (kg/m222.0 ± 0.3 22.4 ± 0.3 22.2 ± 0.6 22.8 ± 0.7 22.4 ± 0.9 22.8 ± 0.6 
Duration of diabetes (years) — 11.1 ± 1.0 8.9 ± 1.1 8.1 ± 1.3 15.9 ± 2.3 20.4 ± 4.2†† 
Smoking index (cigarette-years) 183 ± 43 417 ± 59* 472 ± 88 466 ± 112 289 ± 192 230 ± 117 
Systolic blood pressure (mmHg) 122 ± 3 135 ± 3** 120 ± 2 137 ± 6 159 ± 7††† 165 ± 8††† 
Diastolic blood pressure (mmHg) 77 ± 2 73 ± 1 70 ± 1 76 ± 3 81 ± 3 76 ± 6 
HbA1c (%) — 8.7 ± 0.3 9.2 ± 0.4 8.5 ± 0.4 8.6 ± 0.8 7.0 ± 0.4 
Creatinine (μmol/l) 72 ± 2 113 ± 17 59 ± 2 68 ± 4 90 ± 16 416 ± 68††† 
Log vitamin B12 (pmol/l) — 2.76 ± 0.02 2.78 ± 0.03 2.65 ± 0.04 2.79 ± 0.05 2.82 ± 0.08 
Log folate (nmol/l) — 1.20 ± 0.02 1.20 ± 0.03 1.16 ± 0.03 1.22 ± 0.06 1.22 ± 0.05 
tHcy (μmol/l) 8.7 ± 0.3 12.0 ± 0.7*** 9.6 ± 0.4 11.2 ± 1.1 13.3 ± 1.8 21.6 ± 2.0 
Log tHcy (μmol/l) 0.920 ± 0.016 1.040 ± 0.02*** 0.966 ± 0.018 1.017 ± 0.044 1.092 ± 0.060* 1.319 ± 0.040***††† 

Data are mean ±SE or n.

*

P < 0.05, 0.01, or 0.001 vs. healthy subjects, respectively.

**

P < 0.05, 0.01, or 0.001 vs. healthy subjects, respectively.

***

P < 0.05, 0.01, or 0.001 vs. healthy subjects, respectively.

P < 0.05, 0.01, or 0.001 vs. patients with diabetes with stage 1 nephropathy, respectively.

††

P < 0.05, 0.01, or 0.001 vs. patients with diabetes with stage 1 nephropathy, respectively.

†††

P < 0.05, 0.01, or 0.001 vs. patients with diabetes with stage 1 nephropathy, respectively.

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