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Table 3 —

Standard correlation coefficients (β) on multiple regression analyses for clinical factors affecting log-transformed plasma total homocysteine levels in all 75 patients with diabetes and those of 59 patients with type 2 diabetes with creatinine clearance >60 ml/min

Independent variablesAll patients with diabetes
Patients with diabetes with creatinine clearance >60 ml/min
Model 1Model 2Model 3Model 4
Age 0.123 0.101 0.297 0.241 
Gender 0.133 0.179* 0.213* 0.296* 
Systolic blood pressure 0.151 0.078 0.122 0.003 
HbA1c –0.008 –0.070 0.014 0.165 
Uric acid 0.298 0.321 0.308* 0.368 
Log vitamin B12 –0.331 –0.329 –0.386 –0.375 
Log folate –0.106 –0.177* –0.187 –0.336* 
Creatinine clearance –0.521 –0.529 –0.217 –0.252 
Insulin sensitivity index  –0.245  –0.438 
R2 0.710 0.750 0.434 0.561 
Independent variablesAll patients with diabetes
Patients with diabetes with creatinine clearance >60 ml/min
Model 1Model 2Model 3Model 4
Age 0.123 0.101 0.297 0.241 
Gender 0.133 0.179* 0.213* 0.296* 
Systolic blood pressure 0.151 0.078 0.122 0.003 
HbA1c –0.008 –0.070 0.014 0.165 
Uric acid 0.298 0.321 0.308* 0.368 
Log vitamin B12 –0.331 –0.329 –0.386 –0.375 
Log folate –0.106 –0.177* –0.187 –0.336* 
Creatinine clearance –0.521 –0.529 –0.217 –0.252 
Insulin sensitivity index  –0.245  –0.438 
R2 0.710 0.750 0.434 0.561 

Models 1 and 2 were used for all 75 patients with diabetes, and models 3 and 4 were used for 59 patients with diabetes with creatinine clearance >60 ml/min. In all models, log-transformed plasma tHcy level (log tHcy) was entered as a dependent variable. For sex, female was entered as 0 and male was entered as 1. Creatinine clearance was estimated by Cockcroft-Gault derived equation. The serum levels of vitamin B12 and folate were log-transformed (log vitamin B12 and log folate). Standard correlation coefficients (β) and multiple coefficients of determination (R2) are shown with level of significance.

*

P < 0.05;

P < 0.01;

P < 0.0001.

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