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Table 7 —

Combined haplotype analysis for ABCC8

GenotypenExon 16 −3 C/TExon 18 Thr759ThrSI*AIRglucoseSI*AIRtolbutamide
35 C/C C/C 0.096 (0.061–0.152) 0.023 (0.019–0.028) 
12 C/C C/T 0.098 (0.044–0.220) 0.029 (0.020–0.040) 
45 C/T C/C 0.057 (0.034–0.097) 0.019 (0.015–0.024) 
C/T C/T 0.056 (0.021–0.145) 0.012 (0.008–0.018) 
20 T/T C/C 0.134 (0.065–0.277) 0.027 (0.020–0.036) 
GenotypenExon 16 −3 C/TExon 18 Thr759ThrSI*AIRglucoseSI*AIRtolbutamide
35 C/C C/C 0.096 (0.061–0.152) 0.023 (0.019–0.028) 
12 C/C C/T 0.098 (0.044–0.220) 0.029 (0.020–0.040) 
45 C/T C/C 0.057 (0.034–0.097) 0.019 (0.015–0.024) 
C/T C/T 0.056 (0.021–0.145) 0.012 (0.008–0.018) 
20 T/T C/C 0.134 (0.065–0.277) 0.027 (0.020–0.036) 

Estimated means (95% CIs) are given from the mixed effects model, adjusted for covariates, and transformed back to linear scale. In pairwise comparisons, SI*AIRglucose (DI) was significantly different for genotype 3 vs. genotype 5; SI*AIRtolbutamide (DIT) was significantly different for genotypes 1 vs. 4, 2 vs. 3, 2 vs. 4, 3 vs. 4, 3 vs. 5, and 4 vs. 5 (all <0.05).

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