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Table 2—

Laboratory studies performed in evaluation of neuropathy in 36 patients with IGT

Laboratory test performed*Normal rangenAbnormal results
Vitamin B12 210–911 pg/ml 36 217 in one patient, methylmalonic acid level normal 
Thyroid-stimulating hormone 0.4–5.0 mU/l 35 none 
Serum protein electrophoresis and immunofixation various 35 IgG kappa in one patient 
Anti-nuclear antibody titer ≤1:40 27 titer 1:160 in one patient 
HbAlc 4.1–6.5% 20 none 
Folate 7.8–17.8 ng/ml 19 none 
Thiamine 0.2–2.0 μg/dl 12 none 
Rapid plasma antigen negative none 
Methylmalonic acid <0.4 μmol/l none 
Rheumatoid factor <20 IU/ml none 
Extractable nuclear Ab screen (Smith, RNP, SSA, SSB, sclero) <20 U none 
24-h urine lead 0–31 μg/day none 
24-h urine mercury 0–15 μg/day none 
24-h urine arsenic 0–63.9 μg/day none 
Vitamin B6 5–30 ng/ml none 
Laboratory test performed*Normal rangenAbnormal results
Vitamin B12 210–911 pg/ml 36 217 in one patient, methylmalonic acid level normal 
Thyroid-stimulating hormone 0.4–5.0 mU/l 35 none 
Serum protein electrophoresis and immunofixation various 35 IgG kappa in one patient 
Anti-nuclear antibody titer ≤1:40 27 titer 1:160 in one patient 
HbAlc 4.1–6.5% 20 none 
Folate 7.8–17.8 ng/ml 19 none 
Thiamine 0.2–2.0 μg/dl 12 none 
Rapid plasma antigen negative none 
Methylmalonic acid <0.4 μmol/l none 
Rheumatoid factor <20 IU/ml none 
Extractable nuclear Ab screen (Smith, RNP, SSA, SSB, sclero) <20 U none 
24-h urine lead 0–31 μg/day none 
24-h urine mercury 0–15 μg/day none 
24-h urine arsenic 0–63.9 μg/day none 
Vitamin B6 5–30 ng/ml none 

Data are n.

*

Two or fewer patients underwent the following tests, all of which were normal: anti–double-standard DNA titer, anti-Hu titer, anti-sulfatide antigen titer, anti-MAG titer, human immunodeficiency virus 2 titer, Lyme titer, vitamin E, and cryoglobulins. Many tests listed were performed before referral;

tests recommended for all patients evaluated;

highest HbA1c value obtained for these patients was 6.1%.

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