Table 1—

Pathogenesis of LADA

Factors involved in partial and/or slow  progression of β-cell destruction 
 Genetic predisposition to type 1 diabetes less marked 
 Possible contribution of protective genes toward β-cell destruction 
 Partial regeneration of β-cells 
 Induction of immune tolerance once the immune process toward β-cells has initiated 
 Quantitative/qualitative reduction in the exposure to environmental factors damaging the β-cells 
Factors involved in partial and/or slow  progression of β-cell destruction 
 Genetic predisposition to type 1 diabetes less marked 
 Possible contribution of protective genes toward β-cell destruction 
 Partial regeneration of β-cells 
 Induction of immune tolerance once the immune process toward β-cells has initiated 
 Quantitative/qualitative reduction in the exposure to environmental factors damaging the β-cells 
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