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TABLE 1

Islet transplants expressing IDO result in longer survival time

Islet treatmentnDays of graft survivalMedianMean survival timeSD
Control (i.e, no STZ, no transplant) 29 17, 19, 20, 24, 25, 26 (×3), 28 (×4), 29, 29, 30, 31 (×5), 32, 32, 33, 33, 34, 36, 39, 39, 40 30.0 29.5 5.5 
Neg (uninfected) 19, 20, 26, 28, 33, 33, 35, 35, 59 33.0 32.0 11.8 
Ad-LacZ 10 7, 14, 17, 21, 21, 29, 32, 35, 49, 61 25.0 28.6 16.5 
Ad-IDO 15 24, 30, 32, 37, 37, 40 (×4), 45, 46, 50, 63, 83, 184 40.0* 52.7 39.0 
Islet treatmentnDays of graft survivalMedianMean survival timeSD
Control (i.e, no STZ, no transplant) 29 17, 19, 20, 24, 25, 26 (×3), 28 (×4), 29, 29, 30, 31 (×5), 32, 32, 33, 33, 34, 36, 39, 39, 40 30.0 29.5 5.5 
Neg (uninfected) 19, 20, 26, 28, 33, 33, 35, 35, 59 33.0 32.0 11.8 
Ad-LacZ 10 7, 14, 17, 21, 21, 29, 32, 35, 49, 61 25.0 28.6 16.5 
Ad-IDO 15 24, 30, 32, 37, 37, 40 (×4), 45, 46, 50, 63, 83, 184 40.0* 52.7 39.0 

STZ-treated NODscid recipients were transplanted with untreated or adenovirus-infected islets. Diabetes was adoptively transferred by injection of 2 × 107 spleen cells pooled from naturally diabetic NOD females. Graft survival times are expressed in days postchallenge.

*

Ad-IDO transplant survival curves (Kaplan-Meier analysis) were significantly different than control (no transplant, P < 0.0001), Neg (transplanted with uninfected islets, P = 0.01) and Ad-LacZ–treated grafts (P = 0.02). Note that even when removing the longest surviving transplant (184 days), the difference in survival curves remains statistically significant (P = 0.04).

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