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TABLE 3

Glucose-stimulated insulin secretion of infected islets in vitro

Treatment
Virus3 mmol/l glucose20 mmol/l glucose3 mmol/l glucose
Neg 295 ± 26.2 1241 ± 26.2 327 ± 23.3 
Ad-LacZ 237 ± 21.9 1201 ± 27.6 260 ± 39.6 
Ad-IDO 288 ± 14.8 1174 ± 42.4 271 ± 26.2 
Treatment
Virus3 mmol/l glucose20 mmol/l glucose3 mmol/l glucose
Neg 295 ± 26.2 1241 ± 26.2 327 ± 23.3 
Ad-LacZ 237 ± 21.9 1201 ± 27.6 260 ± 39.6 
Ad-IDO 288 ± 14.8 1174 ± 42.4 271 ± 26.2 

Data are means ± SD. In this experiment, shown as an example, groups of 25 islets were infected with Ad-LacZ and Ad-IDO. Infected islets were compared with uninfected (Neg) islets by culturing them for 4 days before being pulsed with media containing high and low glucose levels. Media were collected after a 30-min exposure to islets. Insulin content measured by ELISA is expressed as picogram insulin per milliliter of media.

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