Hemochromatosis C282Y and H63D polymorphisms in patients with type 2 diabetes and control subjects
| . | Control subjects . | Type 2 diabetic patients . |
|---|---|---|
| C282Y | ||
| All | 196 | 563 |
| CC | 193 (98) | 520 (92) |
| CY and YY | 3 (2) | 43 (7)* |
| OR (95% CI)† | Reference | 5.3 (1.6–17.3) |
| Allele C‡ | 389 | 1,082 |
| Allele Y | 3 | 44 |
| H63D | ||
| All | 196 | 563 |
| HH | 149 (76) | 385 (68) |
| HD and DD | 47 (24) | 178 (32) |
| OR (95% CI)§ | Reference | 1.5 (1.0–2.1) |
| Allele H‖ | 342 | 928 |
| Allele D | 50 | 198 |
| . | Control subjects . | Type 2 diabetic patients . |
|---|---|---|
| C282Y | ||
| All | 196 | 563 |
| CC | 193 (98) | 520 (92) |
| CY and YY | 3 (2) | 43 (7)* |
| OR (95% CI)† | Reference | 5.3 (1.6–17.3) |
| Allele C‡ | 389 | 1,082 |
| Allele Y | 3 | 44 |
| H63D | ||
| All | 196 | 563 |
| HH | 149 (76) | 385 (68) |
| HD and DD | 47 (24) | 178 (32) |
| OR (95% CI)§ | Reference | 1.5 (1.0–2.1) |
| Allele H‖ | 342 | 928 |
| Allele D | 50 | 198 |
Data are n (%), unless otherwise indicated.
One subject was TT homozygote;
χ2 = 8.48, P = 0.0036, type 2 diabetic patients vs. control subjects;
χ2 = 8.55, P = 0.0035, allele C vs. allele Y;
χ2 = 3.71, P = 0.0542, type 2 diabetic patients vs. control subjects;
χ2 = 4.61, P = 0.0317, allele H vs. allele D.