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Table 3 —

Hemochromatosis 282Y and H63D polymorphisms in patients with type 2 diabetes according to renal status

Normoalbuminuria*Nephropathy
282Y 
 All 162 262 
 CC 152 (94) 237 (90) 
 CY and YY  10 (6)   25 (10) 
 OR (95% CI) Reference 1.6 (0.7–3.4) 
 Allele C§ 313 499 
 Allele Y  11  25 
H63D 
 All 162 262 
 HH 122 (75) 165 (63) 
 HD and DD  40 (25)  97 (37) 
 OR (95% CI) Reference 1.8 (1.2–2.8) 
 Allele H 278 417 
 Allele D  46 107 
Normoalbuminuria*Nephropathy
282Y 
 All 162 262 
 CC 152 (94) 237 (90) 
 CY and YY  10 (6)   25 (10) 
 OR (95% CI) Reference 1.6 (0.7–3.4) 
 Allele C§ 313 499 
 Allele Y  11  25 
H63D 
 All 162 262 
 HH 122 (75) 165 (63) 
 HD and DD  40 (25)  97 (37) 
 OR (95% CI) Reference 1.8 (1.2–2.8) 
 Allele H 278 417 
 Allele D  46 107 

Data are n (%), unless otherwise indicated.

*

Only patients with duration of type 2 diabetes ≥10 years after diagnosis;

nephropathy means microalbuminuria or proteinuria;

χ2 = 1.09, P = 0.2968, normoalbuminuria vs. nephropathy;

§

χ2 = 0.62, P = 0.4293, allele C vs. allele Y;

χ2 = 6.4, P = 0.011, normoalbuminuria vs. nephropathy;

χ2 = 4.83, P = 0.0280, allele C vs. allele Y.

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