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Table 2—

RRs of CHD according to clinical diabetes status: the NHS 1976–1996

Nondiabetic throughout the studyDiabetic at baseline (1976)New diabetes diagnosed at follow-up
RRs prior to diagnosisRRs after the diagnosis
Nonfatal MI     
n 1,164 99 124 169 
 Person-years 2,103,936 25,352 66,939 42,061 
 Age-adjusted 1.0 5.65 (4.60–6.96) 3.75 (3.10–4.53) 4.57 (3.87–5.39) 
 Multivariate* 1.0 5.28 (4.28–6.52) 3.17 (2.61–3.85) 3.97 (3.35–4.71) 
Fatal CHD     
n 626 89 — 100 
 Age-adjusted 1.0 9.01 (7.20–11.3) — 2.56 (2.07–3.16) 
 Multivariate 1.0 7.42 (5.91–9.32) — 2.14 (1.72–2.66) 
Total CHD     
n 1,790 188 — 269 
 Age-adjusted 1.0 6.92 (5.94–8.05) — 4.56 (4.00–5.20) 
 Multivariate 1.0 6.21 (5.32–7.25) — 3.93 (3.43–4.51) 
Nondiabetic throughout the studyDiabetic at baseline (1976)New diabetes diagnosed at follow-up
RRs prior to diagnosisRRs after the diagnosis
Nonfatal MI     
n 1,164 99 124 169 
 Person-years 2,103,936 25,352 66,939 42,061 
 Age-adjusted 1.0 5.65 (4.60–6.96) 3.75 (3.10–4.53) 4.57 (3.87–5.39) 
 Multivariate* 1.0 5.28 (4.28–6.52) 3.17 (2.61–3.85) 3.97 (3.35–4.71) 
Fatal CHD     
n 626 89 — 100 
 Age-adjusted 1.0 9.01 (7.20–11.3) — 2.56 (2.07–3.16) 
 Multivariate 1.0 7.42 (5.91–9.32) — 2.14 (1.72–2.66) 
Total CHD     
n 1,790 188 — 269 
 Age-adjusted 1.0 6.92 (5.94–8.05) — 4.56 (4.00–5.20) 
 Multivariate 1.0 6.21 (5.32–7.25) — 3.93 (3.43–4.51) 

Data are n, RR, and RR (95% CI).

*

Models include the following: age (5-year category); time period (10 periods); BMI (<21, 21–22.9, 23–24.9, 25–28.9, 29–31.9, and ≥32 kg/m2); cigarette smoking (never, past, and current smoking of 1–14, 15–24, and ≥25 cigarettes/day); menopausal status (premenopausal, postmenopausal without hormone replacement, postmenopausal with past hormone replacement, and postmenopausal with current hormone replacement); and parental history of MI before 60 years of age.

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