RRs of CHD according to clinical diabetes status: the NHS 1976–1996
| . | Nondiabetic throughout the study . | Diabetic at baseline (1976) . | New diabetes diagnosed at follow-up . | . | |
|---|---|---|---|---|---|
| . | . | . | RRs prior to diagnosis . | RRs after the diagnosis . | |
| Nonfatal MI | |||||
| n | 1,164 | 99 | 124 | 169 | |
| Person-years | 2,103,936 | 25,352 | 66,939 | 42,061 | |
| Age-adjusted | 1.0 | 5.65 (4.60–6.96) | 3.75 (3.10–4.53) | 4.57 (3.87–5.39) | |
| Multivariate* | 1.0 | 5.28 (4.28–6.52) | 3.17 (2.61–3.85) | 3.97 (3.35–4.71) | |
| Fatal CHD | |||||
| n | 626 | 89 | — | 100 | |
| Age-adjusted | 1.0 | 9.01 (7.20–11.3) | — | 2.56 (2.07–3.16) | |
| Multivariate | 1.0 | 7.42 (5.91–9.32) | — | 2.14 (1.72–2.66) | |
| Total CHD | |||||
| n | 1,790 | 188 | — | 269 | |
| Age-adjusted | 1.0 | 6.92 (5.94–8.05) | — | 4.56 (4.00–5.20) | |
| Multivariate | 1.0 | 6.21 (5.32–7.25) | — | 3.93 (3.43–4.51) | |
| . | Nondiabetic throughout the study . | Diabetic at baseline (1976) . | New diabetes diagnosed at follow-up . | . | |
|---|---|---|---|---|---|
| . | . | . | RRs prior to diagnosis . | RRs after the diagnosis . | |
| Nonfatal MI | |||||
| n | 1,164 | 99 | 124 | 169 | |
| Person-years | 2,103,936 | 25,352 | 66,939 | 42,061 | |
| Age-adjusted | 1.0 | 5.65 (4.60–6.96) | 3.75 (3.10–4.53) | 4.57 (3.87–5.39) | |
| Multivariate* | 1.0 | 5.28 (4.28–6.52) | 3.17 (2.61–3.85) | 3.97 (3.35–4.71) | |
| Fatal CHD | |||||
| n | 626 | 89 | — | 100 | |
| Age-adjusted | 1.0 | 9.01 (7.20–11.3) | — | 2.56 (2.07–3.16) | |
| Multivariate | 1.0 | 7.42 (5.91–9.32) | — | 2.14 (1.72–2.66) | |
| Total CHD | |||||
| n | 1,790 | 188 | — | 269 | |
| Age-adjusted | 1.0 | 6.92 (5.94–8.05) | — | 4.56 (4.00–5.20) | |
| Multivariate | 1.0 | 6.21 (5.32–7.25) | — | 3.93 (3.43–4.51) | |
Data are n, RR, and RR (95% CI).
Models include the following: age (5-year category); time period (10 periods); BMI (<21, 21–22.9, 23–24.9, 25–28.9, 29–31.9, and ≥32 kg/m2); cigarette smoking (never, past, and current smoking of 1–14, 15–24, and ≥25 cigarettes/day); menopausal status (premenopausal, postmenopausal without hormone replacement, postmenopausal with past hormone replacement, and postmenopausal with current hormone replacement); and parental history of MI before 60 years of age.