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Table 2—

Plasma apoC-III levels at baseline and after 30 weeks of atorvastatin

PlaceboAtorvastatin
10 mg80 mg
n 71 71 71 
Total apoC-III (mg/l)    
  Baseline 41.3 ± 9.0 39.8 ± 9.5 43.1 ± 9.9 
  30 weeks 41.2 ± 12.0 31.8 ± 10.6* 31.1 ± 11.3* 
  Change (%) −21.1 −27.2 
HDL apoC-III (mg/l)    
  Baseline 17.6 ± 5.2 16.7 ± 5.3 18.4 ± 6.0 
  30 weeks 17.6 ± 8.0 14.1 ± 5.2 13.2 ± 5.8* 
  Change (%) −22.2 −28.3 
LpB:C-III (mg/l)    
  Baseline 23.6 ± 6.8 23.1 ± 7.3 24.7 ± 8.6 
  30 weeks 23.6 ± 7.7 17.7 ± 7.8* 17.9 ± 8.7* 
  Change (%) −23.4 −27.5 
HDL cholestrol (mmol/l)    
  Baseline 1.05 ± 0.21 1.05 ± 0.26 1.04 ± 0.24 
  30 weeks 1.03 ± 0.22 1.11 ± 0.31 1.09 ± 0.28 
  Change (%) −2.0 5.7 4.8 
ApoA-I (mg/l)    
  Baseline 1.41 ± 0.19 1.39 ± 0.20 1.40 ± 0.21 
  30 weeks 1.37 ± 0.18 1.38 ± 0.20 1.34 ± 0.20 
  Change (%) −2.8 −0.7 −4.3 
HDL apoC-III to apoAI (mg/mg)    
  Baseline 9.11 ± 2.97 8.83 ± 2.71 9.76 ± 3.53 
  30 weeks 9.89 ± 6.05 7.48 ± 2.29 7.44 ± 3.42* 
  Change (%) 8.8 −18 −31 
HDL apoC-III to HDL cholesterol (mg/mmol)    
  Baseline 17.1 ± 5.4 16.5 ± 5.2 18.3 ± 6.1 
  30 weeks 18.2 ± 11.4 13.1 ± 4.1 12.5 ± 5.8* 
  Change (%) 6.4 −20.7 −31.7 
PlaceboAtorvastatin
10 mg80 mg
n 71 71 71 
Total apoC-III (mg/l)    
  Baseline 41.3 ± 9.0 39.8 ± 9.5 43.1 ± 9.9 
  30 weeks 41.2 ± 12.0 31.8 ± 10.6* 31.1 ± 11.3* 
  Change (%) −21.1 −27.2 
HDL apoC-III (mg/l)    
  Baseline 17.6 ± 5.2 16.7 ± 5.3 18.4 ± 6.0 
  30 weeks 17.6 ± 8.0 14.1 ± 5.2 13.2 ± 5.8* 
  Change (%) −22.2 −28.3 
LpB:C-III (mg/l)    
  Baseline 23.6 ± 6.8 23.1 ± 7.3 24.7 ± 8.6 
  30 weeks 23.6 ± 7.7 17.7 ± 7.8* 17.9 ± 8.7* 
  Change (%) −23.4 −27.5 
HDL cholestrol (mmol/l)    
  Baseline 1.05 ± 0.21 1.05 ± 0.26 1.04 ± 0.24 
  30 weeks 1.03 ± 0.22 1.11 ± 0.31 1.09 ± 0.28 
  Change (%) −2.0 5.7 4.8 
ApoA-I (mg/l)    
  Baseline 1.41 ± 0.19 1.39 ± 0.20 1.40 ± 0.21 
  30 weeks 1.37 ± 0.18 1.38 ± 0.20 1.34 ± 0.20 
  Change (%) −2.8 −0.7 −4.3 
HDL apoC-III to apoAI (mg/mg)    
  Baseline 9.11 ± 2.97 8.83 ± 2.71 9.76 ± 3.53 
  30 weeks 9.89 ± 6.05 7.48 ± 2.29 7.44 ± 3.42* 
  Change (%) 8.8 −18 −31 
HDL apoC-III to HDL cholesterol (mg/mmol)    
  Baseline 17.1 ± 5.4 16.5 ± 5.2 18.3 ± 6.1 
  30 weeks 18.2 ± 11.4 13.1 ± 4.1 12.5 ± 5.8* 
  Change (%) 6.4 −20.7 −31.7 

Data are means ± SD. Test for difference among the three groups, adjusted for baseline value:

*

P < 0.001;

P = 0.005.

Test for difference versus 10 mg atorvastatin, adjusted for baseline:

P = 0.05.

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