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Table 5—

Univariate and multivariate associations between risk factors and proliferative retinopathy (SREs)

SRE95% CIP
Univariate    
 Amadori albumin 1.45 1.20–1.75 0.0001 
 Circulating TGF-β1 1.29 1.07–1.55 0.007 
 Systolic blood pressure 1.69 1.37–2.10 0.0001 
 HbA1c 2.07 1.68–2.56 0.0001 
Bivariate    
 HbA1c and Amadori albumin    
  HbA1c 1.98 1.57–2.49 0.0001 
  Amadori albumin 1.11 0.89–1.38 0.4 
 Amadori albumin and circulating TGF-β1    
  Amadori albumin 1.40 1.15–1.70 0.004 
  Circulating TGF-β1 1.21 1.00–1.47 0.05 
 Circulating TGF-β1 and HbA1c    
  Circulating TGF-β1 1.20 0.98–1.46 0.08 
  HbA1c 2.01 1.63–2.49 0.0001 
 Circulating TGF-β1 and systolic blood pressure    
  Circulating TGF-β1 1.26 1.04–1.53 0.02 
  Systolic blood pressure 1.67 1.35–2.07 0.0001 
Multivariate    
 Circulating TGF-β1, HbA1c, and Amadori albumin    
  Circulating TGF-β1 1.19 0.97–1.45 0.1 
  HbA1c 1.95 1.55–2.46 0.0001 
  Amadori albumin 1.08 0.87–1.35 0.3 
 Circulating TGF-β1, HbA1c, Amadori albumin, and systolic blood pressure    
  Circulating TGF-β1 1.16 0.95–1.43 0.2 
  HbA1c 1.95 1.54–2.48 0.0001 
  Amadori albumin 1.07 0.85–1.34 0.6 
  Systolic blood pressure 1.66 1.32–2.08 0.0001 
SRE95% CIP
Univariate    
 Amadori albumin 1.45 1.20–1.75 0.0001 
 Circulating TGF-β1 1.29 1.07–1.55 0.007 
 Systolic blood pressure 1.69 1.37–2.10 0.0001 
 HbA1c 2.07 1.68–2.56 0.0001 
Bivariate    
 HbA1c and Amadori albumin    
  HbA1c 1.98 1.57–2.49 0.0001 
  Amadori albumin 1.11 0.89–1.38 0.4 
 Amadori albumin and circulating TGF-β1    
  Amadori albumin 1.40 1.15–1.70 0.004 
  Circulating TGF-β1 1.21 1.00–1.47 0.05 
 Circulating TGF-β1 and HbA1c    
  Circulating TGF-β1 1.20 0.98–1.46 0.08 
  HbA1c 2.01 1.63–2.49 0.0001 
 Circulating TGF-β1 and systolic blood pressure    
  Circulating TGF-β1 1.26 1.04–1.53 0.02 
  Systolic blood pressure 1.67 1.35–2.07 0.0001 
Multivariate    
 Circulating TGF-β1, HbA1c, and Amadori albumin    
  Circulating TGF-β1 1.19 0.97–1.45 0.1 
  HbA1c 1.95 1.55–2.46 0.0001 
  Amadori albumin 1.08 0.87–1.35 0.3 
 Circulating TGF-β1, HbA1c, Amadori albumin, and systolic blood pressure    
  Circulating TGF-β1 1.16 0.95–1.43 0.2 
  HbA1c 1.95 1.54–2.48 0.0001 
  Amadori albumin 1.07 0.85–1.34 0.6 
  Systolic blood pressure 1.66 1.32–2.08 0.0001 

All SREs have been adjusted for age.

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