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TABLE 3

Association of Kir6.2 haplotypes with type 2 diabetes

HaplotypeORP95% CIFrequency
0.87 0.02 0.77–0.99 0.27 
1.09 0.07 0.97–1.23 0.26 
0.91 0.11 0.78–1.06 0.16 
1.04 0.65 0.84–1.30 0.06 
1.26 0.03 0.99–1.60 0.05 
0.96 0.37 0.74–1.23 0.05 
1.23 0.09 0.91–1.66 0.03 
1.10 0.33 0.73–1.64 0.02 
1.00 0.50 0.52–1.93 0.01 
B+D+E 1.15 0.01 1.03–1.29 0.38 
HaplotypeORP95% CIFrequency
0.87 0.02 0.77–0.99 0.27 
1.09 0.07 0.97–1.23 0.26 
0.91 0.11 0.78–1.06 0.16 
1.04 0.65 0.84–1.30 0.06 
1.26 0.03 0.99–1.60 0.05 
0.96 0.37 0.74–1.23 0.05 
1.23 0.09 0.91–1.66 0.03 
1.10 0.33 0.73–1.64 0.02 
1.00 0.50 0.52–1.93 0.01 
B+D+E 1.15 0.01 1.03–1.29 0.38 

Haplotypes of >2% frequency were tested for association with type 2 diabetes in our patient samples and analyzed by Mantel-Haenszel meta-analysis as above. Together, they compose 91% of the haplotypes in our Scandinavian samples. For comparison purposes, we show the pooled results for the three haplotypes (B, D, and E) that carry the K allele of E23K. The frequencies of each haplotype in these samples are strikingly similar to those in the CEPH samples (compare these data with Fig. 3).

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