Association of Kir6.2 haplotypes with type 2 diabetes
| Haplotype . | OR . | P . | 95% CI . | Frequency . |
|---|---|---|---|---|
| A | 0.87 | 0.02 | 0.77–0.99 | 0.27 |
| B | 1.09 | 0.07 | 0.97–1.23 | 0.26 |
| C | 0.91 | 0.11 | 0.78–1.06 | 0.16 |
| D | 1.04 | 0.65 | 0.84–1.30 | 0.06 |
| E | 1.26 | 0.03 | 0.99–1.60 | 0.05 |
| F | 0.96 | 0.37 | 0.74–1.23 | 0.05 |
| G | 1.23 | 0.09 | 0.91–1.66 | 0.03 |
| H | 1.10 | 0.33 | 0.73–1.64 | 0.02 |
| M | 1.00 | 0.50 | 0.52–1.93 | 0.01 |
| B+D+E | 1.15 | 0.01 | 1.03–1.29 | 0.38 |
| Haplotype . | OR . | P . | 95% CI . | Frequency . |
|---|---|---|---|---|
| A | 0.87 | 0.02 | 0.77–0.99 | 0.27 |
| B | 1.09 | 0.07 | 0.97–1.23 | 0.26 |
| C | 0.91 | 0.11 | 0.78–1.06 | 0.16 |
| D | 1.04 | 0.65 | 0.84–1.30 | 0.06 |
| E | 1.26 | 0.03 | 0.99–1.60 | 0.05 |
| F | 0.96 | 0.37 | 0.74–1.23 | 0.05 |
| G | 1.23 | 0.09 | 0.91–1.66 | 0.03 |
| H | 1.10 | 0.33 | 0.73–1.64 | 0.02 |
| M | 1.00 | 0.50 | 0.52–1.93 | 0.01 |
| B+D+E | 1.15 | 0.01 | 1.03–1.29 | 0.38 |
Haplotypes of >2% frequency were tested for association with type 2 diabetes in our patient samples and analyzed by Mantel-Haenszel meta-analysis as above. Together, they compose 91% of the haplotypes in our Scandinavian samples. For comparison purposes, we show the pooled results for the three haplotypes (B, D, and E) that carry the K allele of E23K. The frequencies of each haplotype in these samples are strikingly similar to those in the CEPH samples (compare these data with Fig. 3).