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TABLE 4

Genotype-phenotype correlation of measures of insulin secretion and E23K

Nondiabetic discordant siblingsGeneral
Recessive
AlleleE (39)K (39)P*EE or EK (22)KK (22)P*
Ins index 9.74 ± 5.8 6.89 ± 3.9 0.006 9.64 ± 6.1 7.45 ± 4.4 NS 
Disp index 7.76 ± 3.0 6.30 ± 3.5 0.06 7.69 ± 3.1 7.00 ± 4.0 NS 
Nondiabetic discordant siblingsGeneral
Recessive
AlleleE (39)K (39)P*EE or EK (22)KK (22)P*
Ins index 9.74 ± 5.8 6.89 ± 3.9 0.006 9.64 ± 6.1 7.45 ± 4.4 NS 
Disp index 7.76 ± 3.0 6.30 ± 3.5 0.06 7.69 ± 3.1 7.00 ± 4.0 NS 
Scandinavian control subjects GenotypeEE (168)EK (353)KK (153)PEE/EKKKP
Ins index 5.31 ± 4.0 5.59 ± 4.9 4.52 ± 3.3 EE vs EK:NS 5.50 ± 4.7 4.52 ± 3.3 0.008 
    EE vs KK: 0.028    
    EK vs KK: 0.008    
Disp index 6.32 ± 3.8 5.91 ± 3.6 5.59 ± 3.7 EE vs EK: NS 6.04 ± 3.6 5.47 ± 3.8 NS 
    EE vs KK: 0.08    
    EK vs KK: NS    
Scandinavian control subjects GenotypeEE (168)EK (353)KK (153)PEE/EKKKP
Ins index 5.31 ± 4.0 5.59 ± 4.9 4.52 ± 3.3 EE vs EK:NS 5.50 ± 4.7 4.52 ± 3.3 0.008 
    EE vs KK: 0.028    
    EK vs KK: 0.008    
Disp index 6.32 ± 3.8 5.91 ± 3.6 5.59 ± 3.7 EE vs EK: NS 6.04 ± 3.6 5.47 ± 3.8 NS 
    EE vs KK: 0.08    
    EK vs KK: NS    

Data are means ± SD. We calculated the insulinogenic index (Ins index) and insulin disposition index (Disp index) as described, and compared them across genotypes in nondiabetic siblings discordant for E23K and in all Scandinavian nondiabetic subjects for whom we had OGTT data (see text for details). Number of pairs or individuals is indicated in parentheses. NS, not significant.

*

Paired t test;

two-tailed;

one-tailed.

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