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Table 2—

Two strategies for identification of patients with a clinical diagnosis of type 1 diabetes for HNF-1α gene sequencing

Strategies and screening criteriaNumber fulfilling criteria (%)
HLA-based strategy (ref. 6)  
 Type 1 diabetes 474 
 DRB1*03 and *04 negative 26 (5.5) 
Family history-based stepped strategy  
 Type 1 diabetes 474 
 Affected parent 67 (14.1) 
 Affected parent and GAD antibody titer below 97.5th centile 21 (4.4) 
 Affected parent and GAD and IA-2 antibody titers below 97.5th centile 7 (1.5) 
Strategies and screening criteriaNumber fulfilling criteria (%)
HLA-based strategy (ref. 6)  
 Type 1 diabetes 474 
 DRB1*03 and *04 negative 26 (5.5) 
Family history-based stepped strategy  
 Type 1 diabetes 474 
 Affected parent 67 (14.1) 
 Affected parent and GAD antibody titer below 97.5th centile 21 (4.4) 
 Affected parent and GAD and IA-2 antibody titers below 97.5th centile 7 (1.5) 

Strategies are applied to 474 patients from the BOX study with full GAD and IA-2 antibody data and full HLA class II genotyping data. There are no significant differences in sex ratio or age at diagnosis between this group and the complete BOX study group. Strategy 1 is based on that used by Moller et al. (6). Strategy 2 is based on pedigree and autoantibody data.

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