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Table 2—

Results of 28 treatments with conventional wound care or maggot therapy

Conventional therapyMDT
n wounds monitored 14 14 
Average duration of therapy (weeks) 5.3 (4.1–6.4) 4.7 (3.5–6.0) 
Debridement   
 Initial necrotic tissue (% total area) 44 (22–67) 38 (22–55) 
 Initial surface area of necrotic tissue (cm22.7 (1.2–4.4) 5.0 (2.0–8.0) 
 Necrotic tissue (% total surface area) at week 2 39 (19–58)* 7 (1–13)* 
 Percent change in surface area of necrotic tissue +8% (−8 to 25)* −59 (−125 to 7)* 
 Weekly change in surface area of necrotic tissue (cm2+0.4 (−0.4 to 1.2) −3.9 (−8.4 to −0.6) 
Wound size and healing   
 Initial surface area (cm26.3 (4.2–8.5) 13.3 (6.4–20.2) 
 Surface area at 4 weeks (cm210.9 (6.1–15.7) 11.8 (4.8–18.7) 
 Change in surface area (cm2+5.0 (0.19–9.8)* −3.8 (−7.0 to 0.6)* 
 Weekly change in surface area (cm2+1.15 (0.24–2.1)* −0.78 (−1.6 to 0.1)* 
 Weekly % change in surface area (final/initial) +27 (4.1–50) −2 (−22 to 18) 
 Healing rate at 4 weeks −0.08 (−0.15 to −0.0002)* 0.08 (0.20–0.14)* 
 Healing rate at 8 weeks −0.02 (−0.08 to 0.04)* 0.07 (0.04–0.11)* 
 Wounds completely closed (%) 21 (0–44) 36 (7–65) 
 Average time until wound closure (weeks) 18 (8–28) 15 (3–26) 
Quality of wound base: preparation for graft or surgical closure   
 Initial granulation tissue (% total area) 18 (2–33) 19 (4–35) 
 Granulation tissue at 4 weeks (% total area) 15 (1–30)* 56 (34–77)* 
Conventional therapyMDT
n wounds monitored 14 14 
Average duration of therapy (weeks) 5.3 (4.1–6.4) 4.7 (3.5–6.0) 
Debridement   
 Initial necrotic tissue (% total area) 44 (22–67) 38 (22–55) 
 Initial surface area of necrotic tissue (cm22.7 (1.2–4.4) 5.0 (2.0–8.0) 
 Necrotic tissue (% total surface area) at week 2 39 (19–58)* 7 (1–13)* 
 Percent change in surface area of necrotic tissue +8% (−8 to 25)* −59 (−125 to 7)* 
 Weekly change in surface area of necrotic tissue (cm2+0.4 (−0.4 to 1.2) −3.9 (−8.4 to −0.6) 
Wound size and healing   
 Initial surface area (cm26.3 (4.2–8.5) 13.3 (6.4–20.2) 
 Surface area at 4 weeks (cm210.9 (6.1–15.7) 11.8 (4.8–18.7) 
 Change in surface area (cm2+5.0 (0.19–9.8)* −3.8 (−7.0 to 0.6)* 
 Weekly change in surface area (cm2+1.15 (0.24–2.1)* −0.78 (−1.6 to 0.1)* 
 Weekly % change in surface area (final/initial) +27 (4.1–50) −2 (−22 to 18) 
 Healing rate at 4 weeks −0.08 (−0.15 to −0.0002)* 0.08 (0.20–0.14)* 
 Healing rate at 8 weeks −0.02 (−0.08 to 0.04)* 0.07 (0.04–0.11)* 
 Wounds completely closed (%) 21 (0–44) 36 (7–65) 
 Average time until wound closure (weeks) 18 (8–28) 15 (3–26) 
Quality of wound base: preparation for graft or surgical closure   
 Initial granulation tissue (% total area) 18 (2–33) 19 (4–35) 
 Granulation tissue at 4 weeks (% total area) 15 (1–30)* 56 (34–77)* 

Data are means (median and range), unless otherwise specified. Six wounds received conventional therapy only, six received maggot therapy only, and eight received conventional therapy followed by maggot therapy.

*

Differences in mean values where the probability (P) of a type I error is ≤ 0.05.

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