Patient characteristics for insulin-resistant and insulin-sensitive patients according to MMA and HOMA analysis
| . | Insulin resistant . | Insulin sensitive . | P . |
|---|---|---|---|
| MMA | |||
| n | 35 | 13 | |
| Age (years) | 59 ± 9 | 60 ± 6 | NS |
| Disease duration (months) | 54 ± 42 | 65 ± 46 | NS |
| Body weight (kg) | 94 ± 19 | 85 ± 13 | NS, 0.118 |
| BMI (kg/m2) | 31.8 ± 5.2 | 29.5 ± 3.3 | NS, 0.145 |
| Hypertension (number, %) | 28 (80%) | 10 (77%) | NS |
| HbA1c (%) | 7.1 ± 1.2 | 6.2 ± 0.6 | <0.05 |
| Fasting glucose (mg/dl) | 119 ± 33 | 102 ± 22 | NS, 0.093 |
| Fasting insulin (μU/ml) | 13.1 ± 6.6 | 9.4 ± 3.9 | NS, 0.063 |
| Fasting intact proinsulin (pmol/l) | 19.9 ± 11.7 | 6.0 ± 2.6 | <0.01 |
| Proinsulin/insulin ratio (pmol/mU) | 1.21 ± 0.70 | 0.71 ± 0.36 | <0.05 |
| Fasting resistin (ng/l) | 0.07 ± 0.12 | 0.11 ± 0.18 | NS |
| Fasting adiponectin (μ/ml) | 7.05 ± 4.43 | 9.70 ± 5.66 | NS, 0.095 |
| Fibrinogen (mg/dl) | 2.9 ± 0.9 | 2.6 ± 0.6 | NS |
| HOMA analysis | |||
| n | 34 | 14 | |
| Age (years) | 58 ± 9 | 62 ± 6 | NS, 0.92 |
| Disease duration (months) | 54 ± 34 | 63 ± 59 | NS |
| Body weight (kg) | 96 ± 17 | 81 ± 14 | <0.01 |
| BMI (kg/m2) | 32.3 ± 4.9 | 28.5 ± 3.5 | <0.05 |
| Hypertension (%) | 27 (79%) | 11 (79%) | NS |
| HbA1c (%) | 7.2 ± 1.2 | 6.2 ± 0.8 | <0.05 |
| Fasting glucose (mg/dl) | 126 ± 29 | 86 ± 13 | <0.001 |
| Fasting insulin (μU/ml) | 14.6 ± 5.5 | 6.0 ± 1.7 | <0.001 |
| Fasting intact proinsulin (pmol/l) | 15.4 ± 11.6 | 5.3 ± 2.1 | <0.005 |
| Proinsulin/insulin ratio (pmol/mU) | 1.58 ± 0.66 | 0.66 ± 0.36 | <0.001 |
| Fasting resistin (ng/l) | 0.08 ± 0.15 | 0.08 ± 0.11 | NS |
| Fasting adiponectin (μg/ml) | 6.95 ± 4.33 | 9.77 ± 5.68 | NS, 0.068 |
| Fibrinogen (mg/dl) | 2.8 ± 0.9 | 2.7 ± 0.6 | NS |
| . | Insulin resistant . | Insulin sensitive . | P . |
|---|---|---|---|
| MMA | |||
| n | 35 | 13 | |
| Age (years) | 59 ± 9 | 60 ± 6 | NS |
| Disease duration (months) | 54 ± 42 | 65 ± 46 | NS |
| Body weight (kg) | 94 ± 19 | 85 ± 13 | NS, 0.118 |
| BMI (kg/m2) | 31.8 ± 5.2 | 29.5 ± 3.3 | NS, 0.145 |
| Hypertension (number, %) | 28 (80%) | 10 (77%) | NS |
| HbA1c (%) | 7.1 ± 1.2 | 6.2 ± 0.6 | <0.05 |
| Fasting glucose (mg/dl) | 119 ± 33 | 102 ± 22 | NS, 0.093 |
| Fasting insulin (μU/ml) | 13.1 ± 6.6 | 9.4 ± 3.9 | NS, 0.063 |
| Fasting intact proinsulin (pmol/l) | 19.9 ± 11.7 | 6.0 ± 2.6 | <0.01 |
| Proinsulin/insulin ratio (pmol/mU) | 1.21 ± 0.70 | 0.71 ± 0.36 | <0.05 |
| Fasting resistin (ng/l) | 0.07 ± 0.12 | 0.11 ± 0.18 | NS |
| Fasting adiponectin (μ/ml) | 7.05 ± 4.43 | 9.70 ± 5.66 | NS, 0.095 |
| Fibrinogen (mg/dl) | 2.9 ± 0.9 | 2.6 ± 0.6 | NS |
| HOMA analysis | |||
| n | 34 | 14 | |
| Age (years) | 58 ± 9 | 62 ± 6 | NS, 0.92 |
| Disease duration (months) | 54 ± 34 | 63 ± 59 | NS |
| Body weight (kg) | 96 ± 17 | 81 ± 14 | <0.01 |
| BMI (kg/m2) | 32.3 ± 4.9 | 28.5 ± 3.5 | <0.05 |
| Hypertension (%) | 27 (79%) | 11 (79%) | NS |
| HbA1c (%) | 7.2 ± 1.2 | 6.2 ± 0.8 | <0.05 |
| Fasting glucose (mg/dl) | 126 ± 29 | 86 ± 13 | <0.001 |
| Fasting insulin (μU/ml) | 14.6 ± 5.5 | 6.0 ± 1.7 | <0.001 |
| Fasting intact proinsulin (pmol/l) | 15.4 ± 11.6 | 5.3 ± 2.1 | <0.005 |
| Proinsulin/insulin ratio (pmol/mU) | 1.58 ± 0.66 | 0.66 ± 0.36 | <0.001 |
| Fasting resistin (ng/l) | 0.08 ± 0.15 | 0.08 ± 0.11 | NS |
| Fasting adiponectin (μg/ml) | 6.95 ± 4.33 | 9.77 ± 5.68 | NS, 0.068 |
| Fibrinogen (mg/dl) | 2.8 ± 0.9 | 2.7 ± 0.6 | NS |
Data are means ± SD unless otherwise indicated.