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Table 1—

Patient characteristics for insulin-resistant and insulin-sensitive patients according to MMA and HOMA analysis

Insulin resistantInsulin sensitiveP
MMA    
n 35 13  
 Age (years) 59 ± 9 60 ± 6 NS 
 Disease duration (months) 54 ± 42 65 ± 46 NS 
 Body weight (kg) 94 ± 19 85 ± 13 NS, 0.118 
 BMI (kg/m231.8 ± 5.2 29.5 ± 3.3 NS, 0.145 
 Hypertension (number, %) 28 (80%) 10 (77%) NS 
 HbA1c (%) 7.1 ± 1.2 6.2 ± 0.6 <0.05 
 Fasting glucose (mg/dl) 119 ± 33 102 ± 22 NS, 0.093 
 Fasting insulin (μU/ml) 13.1 ± 6.6 9.4 ± 3.9 NS, 0.063 
 Fasting intact proinsulin (pmol/l) 19.9 ± 11.7 6.0 ± 2.6 <0.01 
 Proinsulin/insulin ratio (pmol/mU) 1.21 ± 0.70 0.71 ± 0.36 <0.05 
 Fasting resistin (ng/l) 0.07 ± 0.12 0.11 ± 0.18 NS 
 Fasting adiponectin (μ/ml) 7.05 ± 4.43 9.70 ± 5.66 NS, 0.095 
 Fibrinogen (mg/dl) 2.9 ± 0.9 2.6 ± 0.6 NS 
HOMA analysis    
n 34 14  
 Age (years) 58 ± 9 62 ± 6 NS, 0.92 
 Disease duration (months) 54 ± 34 63 ± 59 NS 
 Body weight (kg) 96 ± 17 81 ± 14 <0.01 
 BMI (kg/m232.3 ± 4.9 28.5 ± 3.5 <0.05 
 Hypertension (%) 27 (79%) 11 (79%) NS 
 HbA1c (%) 7.2 ± 1.2 6.2 ± 0.8 <0.05 
 Fasting glucose (mg/dl) 126 ± 29 86 ± 13 <0.001 
 Fasting insulin (μU/ml) 14.6 ± 5.5 6.0 ± 1.7 <0.001 
 Fasting intact proinsulin (pmol/l) 15.4 ± 11.6 5.3 ± 2.1 <0.005 
 Proinsulin/insulin ratio (pmol/mU) 1.58 ± 0.66 0.66 ± 0.36 <0.001 
 Fasting resistin (ng/l) 0.08 ± 0.15 0.08 ± 0.11 NS 
 Fasting adiponectin (μg/ml) 6.95 ± 4.33 9.77 ± 5.68 NS, 0.068 
 Fibrinogen (mg/dl) 2.8 ± 0.9 2.7 ± 0.6 NS 
Insulin resistantInsulin sensitiveP
MMA    
n 35 13  
 Age (years) 59 ± 9 60 ± 6 NS 
 Disease duration (months) 54 ± 42 65 ± 46 NS 
 Body weight (kg) 94 ± 19 85 ± 13 NS, 0.118 
 BMI (kg/m231.8 ± 5.2 29.5 ± 3.3 NS, 0.145 
 Hypertension (number, %) 28 (80%) 10 (77%) NS 
 HbA1c (%) 7.1 ± 1.2 6.2 ± 0.6 <0.05 
 Fasting glucose (mg/dl) 119 ± 33 102 ± 22 NS, 0.093 
 Fasting insulin (μU/ml) 13.1 ± 6.6 9.4 ± 3.9 NS, 0.063 
 Fasting intact proinsulin (pmol/l) 19.9 ± 11.7 6.0 ± 2.6 <0.01 
 Proinsulin/insulin ratio (pmol/mU) 1.21 ± 0.70 0.71 ± 0.36 <0.05 
 Fasting resistin (ng/l) 0.07 ± 0.12 0.11 ± 0.18 NS 
 Fasting adiponectin (μ/ml) 7.05 ± 4.43 9.70 ± 5.66 NS, 0.095 
 Fibrinogen (mg/dl) 2.9 ± 0.9 2.6 ± 0.6 NS 
HOMA analysis    
n 34 14  
 Age (years) 58 ± 9 62 ± 6 NS, 0.92 
 Disease duration (months) 54 ± 34 63 ± 59 NS 
 Body weight (kg) 96 ± 17 81 ± 14 <0.01 
 BMI (kg/m232.3 ± 4.9 28.5 ± 3.5 <0.05 
 Hypertension (%) 27 (79%) 11 (79%) NS 
 HbA1c (%) 7.2 ± 1.2 6.2 ± 0.8 <0.05 
 Fasting glucose (mg/dl) 126 ± 29 86 ± 13 <0.001 
 Fasting insulin (μU/ml) 14.6 ± 5.5 6.0 ± 1.7 <0.001 
 Fasting intact proinsulin (pmol/l) 15.4 ± 11.6 5.3 ± 2.1 <0.005 
 Proinsulin/insulin ratio (pmol/mU) 1.58 ± 0.66 0.66 ± 0.36 <0.001 
 Fasting resistin (ng/l) 0.08 ± 0.15 0.08 ± 0.11 NS 
 Fasting adiponectin (μg/ml) 6.95 ± 4.33 9.77 ± 5.68 NS, 0.068 
 Fibrinogen (mg/dl) 2.8 ± 0.9 2.7 ± 0.6 NS 

Data are means ± SD unless otherwise indicated.

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