American Diabetes Association

TABLE 1

Relative contribution of clearance systems to Ca²⁺ removal^*

[Ca²⁺]_i	0.5 μmol/l	0.9 μmol/l	1.5 μmol/l^*	1.9 μmol/l
SERCA pumps	68	61	^†	^†
PMCA pumps	16	12	30^†	35^†
NCX	13	16	63^†	62^†
Total accounted for	97	89	93^†	97^†

[Ca²⁺]_i	0.5 μmol/l	0.9 μmol/l	1.5 μmol/l^*	1.9 μmol/l
SERCA pumps	68	61	^†	^†
PMCA pumps	16	12	30^†	35^†
NCX	13	16	63^†	62^†
Total accounted for	97	89	93^†	97^†

Data are %.

The rate of [Ca²⁺]_i decay, d[Ca²⁺]_i/dt, was determined at four [Ca²⁺]_i levels from averaged records. Table shows the percentage of the rate that was inhibited by appropriate blocking conditions.

†

Values from TG-pretreated cells, which represent the percentage contribution of the PMCA and NCX to the clearance (by the Na8.8 and Li7.4 methods) when SERCA pumps are disabled.

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