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TABLE 3

Renal response to AngII in groups segregated by N/D ratio

ParameterNormal N/D ratio
High N/D ratio
Baseline1 ng · kg−1 · min−13 ng · kg−1 · min−1RecoveryBaseline1 ng · kg−1 · min−13 ng · kg−1 · min−1Recovery
GFR (ml · min−1 · 1.73 m−2128 ± 46 118 ± 41 113 ± 29* 117 ± 35 142 ± 31 142 ± 25 141 ± 24 137 ± 22 
ERPF (ml · min−1 · 1.73 m−2698 ± 124 561 ± 90 480 ± 101* 502 ± 107 756 ± 242 617 ± 175 532 ± 158* 616 ± 190 
RBF (ml · min−1 · 1.73 m−21,250 ± 454 1021 ± 334 881 ± 291* 1,012 ± 337 1,166 ± 289 990 ± 289 829 ± 203* 909 ± 243 
FF 0.18 ± 0.05 0.21 ± 0.06 0.24 ± 0.04* 0.24 ± 0.06 0.20 ± 0.05 0.24 ± 0.04 0.28 ± 0.06* 0.23 ± 0.05 
RVR (mmHg · l−1 · min−177 ± 13 101 ± 19* 134 ± 31* 110 ± 29 64 ± 16 89 ± 27 119 ± 34* 86 ± 24 
MAP (mmHg) 83 ± 5 90 ± 8 101 ± 10* 85 ± 5 74 ± 9 83 ± 9 97 ± 16* 81 ± 11 
ParameterNormal N/D ratio
High N/D ratio
Baseline1 ng · kg−1 · min−13 ng · kg−1 · min−1RecoveryBaseline1 ng · kg−1 · min−13 ng · kg−1 · min−1Recovery
GFR (ml · min−1 · 1.73 m−2128 ± 46 118 ± 41 113 ± 29* 117 ± 35 142 ± 31 142 ± 25 141 ± 24 137 ± 22 
ERPF (ml · min−1 · 1.73 m−2698 ± 124 561 ± 90 480 ± 101* 502 ± 107 756 ± 242 617 ± 175 532 ± 158* 616 ± 190 
RBF (ml · min−1 · 1.73 m−21,250 ± 454 1021 ± 334 881 ± 291* 1,012 ± 337 1,166 ± 289 990 ± 289 829 ± 203* 909 ± 243 
FF 0.18 ± 0.05 0.21 ± 0.06 0.24 ± 0.04* 0.24 ± 0.06 0.20 ± 0.05 0.24 ± 0.04 0.28 ± 0.06* 0.23 ± 0.05 
RVR (mmHg · l−1 · min−177 ± 13 101 ± 19* 134 ± 31* 110 ± 29 64 ± 16 89 ± 27 119 ± 34* 86 ± 24 
MAP (mmHg) 83 ± 5 90 ± 8 101 ± 10* 85 ± 5 74 ± 9 83 ± 9 97 ± 16* 81 ± 11 

Data are means ± SE.

*

P < 0.05 vs. baseline;

P < 0.05 vs. response of normal N/D ratio group;

P < 0.05 vs. baseline value of normal N/D ratio group.

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