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Table 1—

Antihypertensive agents and their effects on adult hypertensive diabetic patients

ClassEffects on coronary events rates*Effects on progression of renal diseaseEffects on stroke
Thiazide diuretics Beneficial (A)* Unknown Beneficial (A) 
Loop diuretics Unknown Unknown Unknown 
Centrally acting adrenergic agents Unknown Unknown Unknown 
β-Blockers Beneficial (A) Beneficial (A) Beneficial (A) 
α-Blockers Controversial Unknown Unknown 
DCCBs Controversial Controversial Beneficial (A) 
NDCCBs Unknown Beneficial (C) Unknown 
ACE inhibitors Beneficial (A) Beneficial (A) Beneficial (A) 
Angiotensin-2 antagonists Unknown Beneficial (A) Unknown 
ClassEffects on coronary events rates*Effects on progression of renal diseaseEffects on stroke
Thiazide diuretics Beneficial (A)* Unknown Beneficial (A) 
Loop diuretics Unknown Unknown Unknown 
Centrally acting adrenergic agents Unknown Unknown Unknown 
β-Blockers Beneficial (A) Beneficial (A) Beneficial (A) 
α-Blockers Controversial Unknown Unknown 
DCCBs Controversial Controversial Beneficial (A) 
NDCCBs Unknown Beneficial (C) Unknown 
ACE inhibitors Beneficial (A) Beneficial (A) Beneficial (A) 
Angiotensin-2 antagonists Unknown Beneficial (A) Unknown 
*

Level of evidence for summary

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