Anthropometric and metabolic characteristics of 510 glucose-tolerant Danish white subjects stratified according to SLC2A10 Ala206Thr genotype
| Ala206Thr . | Ala/Ala . | Ala/Thr + Thr/Thr . | P . |
|---|---|---|---|
| n (men/women) | 469 (217/252) | 38 (20/18) | |
| Age (years) | 56 ± 10 | 58 ± 9 | |
| BMI (kg/m2) | 25.7 ± 3.7 | 26.0 ± 3.4 | 0.8 |
| Plasma glucose | |||
| Fasting (mmol/l) | 5.1 ± 0.4 | 5.0 ± 0.4 | 0.2 |
| 30-min post-OGTT (mmol/l) | 7.7 ± 1.4 | 7.8 ± 1.4 | 1.0 |
| 60-min post-OGTT (mmol/l) | 7.5 ± 1.9 | 7.4 ± 2.1 | 0.6 |
| 120-min post-OGTT (mmol/l) | 5.4 ± 1.2 | 5.5 ± 1.2 | 0.7 |
| Post-OGTT AUC (min · mmol/l) | 195 ± 119 | 206 ± 131 | 0.8 |
| Serum insulin | |||
| Fasting (pmol/l) | 39 ± 19 | 32 ± 17 | 0.002 |
| 30-min post-OGTT (pmol/l) | 261 ± 148 | 217 ± 122 | 0.03 |
| 60-min post-OGTT (pmol/l) | 310 ± 194 | 276 ± 217 | 0.05 |
| 120-min post-OGTT (pmol/l) | 183 ± 123 | 163 ± 117 | 0.2 |
| Post-OGTT AUC (min · pmol/l) | 23,021 ± 12,933 | 20,397 ± 14,358 | 0.04 |
| Insulinogenic index | 29.0 ± 17.9 | 23.2 ± 11.8 | 0.03 |
| Ala206Thr . | Ala/Ala . | Ala/Thr + Thr/Thr . | P . |
|---|---|---|---|
| n (men/women) | 469 (217/252) | 38 (20/18) | |
| Age (years) | 56 ± 10 | 58 ± 9 | |
| BMI (kg/m2) | 25.7 ± 3.7 | 26.0 ± 3.4 | 0.8 |
| Plasma glucose | |||
| Fasting (mmol/l) | 5.1 ± 0.4 | 5.0 ± 0.4 | 0.2 |
| 30-min post-OGTT (mmol/l) | 7.7 ± 1.4 | 7.8 ± 1.4 | 1.0 |
| 60-min post-OGTT (mmol/l) | 7.5 ± 1.9 | 7.4 ± 2.1 | 0.6 |
| 120-min post-OGTT (mmol/l) | 5.4 ± 1.2 | 5.5 ± 1.2 | 0.7 |
| Post-OGTT AUC (min · mmol/l) | 195 ± 119 | 206 ± 131 | 0.8 |
| Serum insulin | |||
| Fasting (pmol/l) | 39 ± 19 | 32 ± 17 | 0.002 |
| 30-min post-OGTT (pmol/l) | 261 ± 148 | 217 ± 122 | 0.03 |
| 60-min post-OGTT (pmol/l) | 310 ± 194 | 276 ± 217 | 0.05 |
| 120-min post-OGTT (pmol/l) | 183 ± 123 | 163 ± 117 | 0.2 |
| Post-OGTT AUC (min · pmol/l) | 23,021 ± 12,933 | 20,397 ± 14,358 | 0.04 |
| Insulinogenic index | 29.0 ± 17.9 | 23.2 ± 11.8 | 0.03 |
Data are means ± SD. Values of insulin or values derived from insulin were logarithmically transformed before statistical analysis. Calculated P values were adjusted for age, sex, and BMI and were calculated assuming a dominant model for the penetrance of the Thr allele. The insulinogenic index was calculated as fasting serum insulin (pmol/l) subtracted from 30-min post-OGTT serum insulin (pmol/l) and divided by 30-min post-OGTT plasma glucose (mmol/l).