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TABLE 1

Binding, internalization, and degradation of insulin and insulin analogs in rat myoblasts

Binding (fmol/2 × 105 cells)Internalization (cpm × 102)Degradation (%)
Human insulin 2.8 ± 0.06 2,200 ± 200 6.3 ± 0.5 
HMR 1964 2.2 ± 0.1 1,600 ± 300 3.0 ± 0.4 
AspB10 4.2 ± 0.05* 3,400 ± 400* 2.6 ± 0.7 
HMR 1153 4.4 ± 0.01* 5,500 ± 1,100* 5.0 ± 0.3 
Binding (fmol/2 × 105 cells)Internalization (cpm × 102)Degradation (%)
Human insulin 2.8 ± 0.06 2,200 ± 200 6.3 ± 0.5 
HMR 1964 2.2 ± 0.1 1,600 ± 300 3.0 ± 0.4 
AspB10 4.2 ± 0.05* 3,400 ± 400* 2.6 ± 0.7 
HMR 1153 4.4 ± 0.01* 5,500 ± 1,100* 5.0 ± 0.3 

Data are means ± SE taken from 4–5 separate experiments. Binding, internalization, and degradation of insulin and insulin analogs was determined as described in research design and methods.

*

Significantly different from human insulin and HMR 1964 at P < 0.05;

significantly different from HMR 1964 and AspB10 at P < 0.05.

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