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Table 2—

Discontinuation of initial prescribed antihypertensive drug class within 2 years of initial prescription, by sex

Drug classDrug class-specific discontinuation rates (%)
P value for comparison between men and women
OverallWomenMen
ACE inhibitors 44.7 49 41 <0.0001 
Angiotensin II receptor blockers 39.4 37 43 0.56 
β-Blockers 61.6 61 62 0.72 
Calcium channel blockers 53.6 53 55 0.43 
Thiazides 70.0 69 71 0.28 
Drug classDrug class-specific discontinuation rates (%)
P value for comparison between men and women
OverallWomenMen
ACE inhibitors 44.7 49 41 <0.0001 
Angiotensin II receptor blockers 39.4 37 43 0.56 
β-Blockers 61.6 61 62 0.72 
Calcium channel blockers 53.6 53 55 0.43 
Thiazides 70.0 69 71 0.28 

Note that drug class-specific discontinuation rates include those patients who discontinued all antihypertensive therapy (as in Fig. 2) plus those patients whose medication was switched from one drug class to another within the study time frame.

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