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Table 3—

The best-fit multiple regression model for risk of CD in children with type 1 diabetes

Genetic factorOR (95%CI)Wald P
HLA-DQB1*02-DQA1*05   
    Double dose* 4.45 (1.75–11.3) 0.002 
    Single dose* 2.04 (1.11–3.76) 0.022 
TNF-α −308A 1.87 (1.10–3.20) 0.021 
IL-1α −889T 0.58 (0.37–0.93) 0.023 
Genetic factorOR (95%CI)Wald P
HLA-DQB1*02-DQA1*05   
    Double dose* 4.45 (1.75–11.3) 0.002 
    Single dose* 2.04 (1.11–3.76) 0.022 
TNF-α −308A 1.87 (1.10–3.20) 0.021 
IL-1α −889T 0.58 (0.37–0.93) 0.023 

The variables associated with CD in the univariate model were used to build a step-up multiple model. The predictor variables included two indicator variables showing a double and single dose of HLA-DQB1*02-DQA1*05 and dichotomous variables showing the phenotypic positivity for a given allele of a cytokine SNP. The adequacy of inclusion of predictor variables into the model was tested using the log-likelihood ratio test. No interaction terms improved the model. The effect of HLA-DQB1*0302-DQA1*03 observed in the univariate analysis was lost after adjusting for HLA-DQB1*02-DQA1*05.

*

Two indicator variables compare the levels of risk relative to an absence of HLA-DQB1*02-DQA1*05.

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