Skip to Main Content
TABLE 1

Clinical and metabolic characteristics among young and older MZ and DZ twins

Young twins
Older twins
MZDZMZDZ
n (M/F) 66 (36/30) 44 (24/20) 42 (22/20) 44 (16/28) 
Age (years) 28.2 ± 1.8 27.5 ± 1.9 61.6 ± 2.6 62.0 ± 2.0 
Birth weight (g) 2,639.8 ± 90.1 2,561.8 ± 85.2 2,664.4 ± 72.4 2,703.4 ± 103.7 
BMI (kg/m224.3 ± 0.5 23.8 ± 0.6 26.2 ± 0.7 26.1 ± 0.9 
WHR 0.85 ± 0.02 0.82 ± 0.02 0.90 ± 0.02 0.87 ± 0.02 
FFM (kg) 54.9 ± 1.9 54.3 ± 2.6 51.1 ± 2.7 49.4 ± 2.4 
HGP     
    Basal 3.10 ± 0.08 3.04 ± 0.08 3.02 ± 0.08 3.10 ± 0.08 
    Clamp 1.49 ± 0.07 1.49 ± 0.06 1.57 ± 0.09 1.70 ± 0.14 
Glucose disposal (Rd    
    Basal 3.10 ± 0.08 3.01 ± 0.07 3.05 ± 0.08 3.14 ± 0.07 
    Clamp 12.2 ± 0.53 11.0 ± 0.49 8.86 ± 0.59* 10.84 ± 0.57 
Glucose oxidation     
    Basal 2.17 ± 0.14 2.02 ± 0.15 1.82 ± 0.19 1.75 ± 0.13 
    Clamp 4.72 ± 0.19 4.54 ± 0.29 3.88 ± 0.26 4.27 ± 0.21 
Fat oxidation     
    Basal 1.25 ± 0.06 1.32 ± 0.07 1.36 ± 0.08 1.52 ± 0.07 
    Clamp 0.32 ± 0.05 0.38 ± 0.09 0.56 ± 0.07 0.58 ± 0.08 
Glycolytic flux     
    Basal 1.62 ± 0.13 2.00 ± 0.19 2.11 ± 0.17 2.28 ± 0.20 
    Clamp 4.49 ± 0.29 4.37 ± 0.30 3.80 ± 0.30 4.01 ± 0.42 
NOGM     
    Basal 0.93 ± 0.12 0.99 ± 0.14 1.22 ± 0.17 1.42 ± 0.12 
    Clamp 7.53 ± 0.46 6.41 ± 0.42 4.99 ± 0.52* 6.67 ± 0.52 
Exogenous glucose storage     
    Basal 1.48 ± 0.14 1.01 ± 0.20 0.94 ± 0.14 0.86 ± 0.18 
    Clamp 7.75 ± 0.44 6.59 ± 0.49 5.06 ± 0.53* 6.83 ± 0.55 
Insulin secretion (Di2.11E-7 ± 1.14E-7 2.32E-7 ± 1.39E-7 1.10E-7 ± 0.78E-7 1.32E-7 ± 0.92E-7 
Young twins
Older twins
MZDZMZDZ
n (M/F) 66 (36/30) 44 (24/20) 42 (22/20) 44 (16/28) 
Age (years) 28.2 ± 1.8 27.5 ± 1.9 61.6 ± 2.6 62.0 ± 2.0 
Birth weight (g) 2,639.8 ± 90.1 2,561.8 ± 85.2 2,664.4 ± 72.4 2,703.4 ± 103.7 
BMI (kg/m224.3 ± 0.5 23.8 ± 0.6 26.2 ± 0.7 26.1 ± 0.9 
WHR 0.85 ± 0.02 0.82 ± 0.02 0.90 ± 0.02 0.87 ± 0.02 
FFM (kg) 54.9 ± 1.9 54.3 ± 2.6 51.1 ± 2.7 49.4 ± 2.4 
HGP     
    Basal 3.10 ± 0.08 3.04 ± 0.08 3.02 ± 0.08 3.10 ± 0.08 
    Clamp 1.49 ± 0.07 1.49 ± 0.06 1.57 ± 0.09 1.70 ± 0.14 
Glucose disposal (Rd    
    Basal 3.10 ± 0.08 3.01 ± 0.07 3.05 ± 0.08 3.14 ± 0.07 
    Clamp 12.2 ± 0.53 11.0 ± 0.49 8.86 ± 0.59* 10.84 ± 0.57 
Glucose oxidation     
    Basal 2.17 ± 0.14 2.02 ± 0.15 1.82 ± 0.19 1.75 ± 0.13 
    Clamp 4.72 ± 0.19 4.54 ± 0.29 3.88 ± 0.26 4.27 ± 0.21 
Fat oxidation     
    Basal 1.25 ± 0.06 1.32 ± 0.07 1.36 ± 0.08 1.52 ± 0.07 
    Clamp 0.32 ± 0.05 0.38 ± 0.09 0.56 ± 0.07 0.58 ± 0.08 
Glycolytic flux     
    Basal 1.62 ± 0.13 2.00 ± 0.19 2.11 ± 0.17 2.28 ± 0.20 
    Clamp 4.49 ± 0.29 4.37 ± 0.30 3.80 ± 0.30 4.01 ± 0.42 
NOGM     
    Basal 0.93 ± 0.12 0.99 ± 0.14 1.22 ± 0.17 1.42 ± 0.12 
    Clamp 7.53 ± 0.46 6.41 ± 0.42 4.99 ± 0.52* 6.67 ± 0.52 
Exogenous glucose storage     
    Basal 1.48 ± 0.14 1.01 ± 0.20 0.94 ± 0.14 0.86 ± 0.18 
    Clamp 7.75 ± 0.44 6.59 ± 0.49 5.06 ± 0.53* 6.83 ± 0.55 
Insulin secretion (Di2.11E-7 ± 1.14E-7 2.32E-7 ± 1.39E-7 1.10E-7 ± 0.78E-7 1.32E-7 ± 0.92E-7 

Data are means ± SE. All metabolic turnover rates are expressed as mg · kg FFM−1 · min−1.

*

P < 0.05 for MZ vs. DZ within same age-group. FFM, fat-free mass; WHR, waist-to-hip ratio.

Close Modal

or Create an Account

Close Modal
Close Modal