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TABLE 3

Lipolysis in human isolated adipocytes from subcutaneous needle biopsies based on genotypes for SNP rs2072907 in nonobese and obese subjects

Stimulation11122211 + 12P value
Nonobese      
    n (men/women) 27/38 10/22 1/3 37/60 0.61 (0.87) 
    Age (years) 36 (30–47) 37 (33–46) 32 (28–48) 36 (31–47) 0.85 (0.61) 
    BMI (kg/m223.4 (21.8–24.2) 23.1 (21.2–24.2) 23.5 (17.8–24.3) 23.4 (21.6–24.2) 0.81 (0.91) 
    Basal lipolysis (μg glycerol ·     g lipid−1 · 2 h−10.79 (0.52–1.30) 0.76 (0.53–1.24) 1.44 (0.45–1.55) 0.78 (0.53–1.25) 0.80 (0.51) 
 [64] [32] [3] [96]  
    Isoprenaline 6.27 (4.52–8.80) 6.56 (4.26–8.63) 7.90 (4.37–8.25) 6.27 (4.41–8.66) 0.98 (0.82) 
 [63] [29] [3] [92]  
    Norepinephrine 3.19 (2.02–4.65) 3.25 (2.39–5.96) 2.81 (2.74–4.74) 3.25 (2.21–4.92) 0.73 (0.89) 
 [62] [32] [3] [94]  
Obese      
    n (men/women) 20/69 11/21 2/7 31/90 0.40 (0.82) 
    Age (years) 39 (28/48) 37 (30–46) 47 (25–52) 38 (29–48) 0.95 (0.77) 
    BMI (kg/m240.4 (35.6–44.8) 38.3 (33.4–41.1) 35.9 (31.4–40.4) 39.5 (35.4–43.7) 0.063 (0.13) 
    Basal lipolysis (μg glycerol ·     g lipid−1 · 2 h−11.28 (0.79–1.83) 1.32 (0.76–1.92) 0.68 (0.43–0.96) 1.30 (0.79–1.83) 0.025 (0.007) 
 [89] [32] [9] [121]  
    Isoprenaline 4.57 (3.13–5.75) 4.19 (3.15–4.88) 3.56 (1.80–4.33) 4.41 (3.13–5.57) 0.13 (0.055) 
 [88] [31] [9] [119]  
    Norepinephrine 3.08 (2.10–4.06) 2.77 (2.27–3.86) 2.57 (1.31–3.09) 2.90 (2.14–4.00) 0.30 (0.12) 
 [88] [32] [9] [120]  
Stimulation11122211 + 12P value
Nonobese      
    n (men/women) 27/38 10/22 1/3 37/60 0.61 (0.87) 
    Age (years) 36 (30–47) 37 (33–46) 32 (28–48) 36 (31–47) 0.85 (0.61) 
    BMI (kg/m223.4 (21.8–24.2) 23.1 (21.2–24.2) 23.5 (17.8–24.3) 23.4 (21.6–24.2) 0.81 (0.91) 
    Basal lipolysis (μg glycerol ·     g lipid−1 · 2 h−10.79 (0.52–1.30) 0.76 (0.53–1.24) 1.44 (0.45–1.55) 0.78 (0.53–1.25) 0.80 (0.51) 
 [64] [32] [3] [96]  
    Isoprenaline 6.27 (4.52–8.80) 6.56 (4.26–8.63) 7.90 (4.37–8.25) 6.27 (4.41–8.66) 0.98 (0.82) 
 [63] [29] [3] [92]  
    Norepinephrine 3.19 (2.02–4.65) 3.25 (2.39–5.96) 2.81 (2.74–4.74) 3.25 (2.21–4.92) 0.73 (0.89) 
 [62] [32] [3] [94]  
Obese      
    n (men/women) 20/69 11/21 2/7 31/90 0.40 (0.82) 
    Age (years) 39 (28/48) 37 (30–46) 47 (25–52) 38 (29–48) 0.95 (0.77) 
    BMI (kg/m240.4 (35.6–44.8) 38.3 (33.4–41.1) 35.9 (31.4–40.4) 39.5 (35.4–43.7) 0.063 (0.13) 
    Basal lipolysis (μg glycerol ·     g lipid−1 · 2 h−11.28 (0.79–1.83) 1.32 (0.76–1.92) 0.68 (0.43–0.96) 1.30 (0.79–1.83) 0.025 (0.007) 
 [89] [32] [9] [121]  
    Isoprenaline 4.57 (3.13–5.75) 4.19 (3.15–4.88) 3.56 (1.80–4.33) 4.41 (3.13–5.57) 0.13 (0.055) 
 [88] [31] [9] [119]  
    Norepinephrine 3.08 (2.10–4.06) 2.77 (2.27–3.86) 2.57 (1.31–3.09) 2.90 (2.14–4.00) 0.30 (0.12) 
 [88] [32] [9] [120]  

Data are presented as median with interquartile range within parenthesis (25th–75th percentile) and number of observations within brackets [n]. The P value within parentheses represents the comparison between the genotypes 11 + 12 and 22. P values are calculated using Kruskal-Wallis or Wilcoxon’s test. 1, major allele; 2, minor allele.

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