Lipolysis in human isolated adipocytes from subcutaneous needle biopsies based on genotypes for SNP rs2072907 in nonobese and obese subjects
| Stimulation . | 11 . | 12 . | 22 . | 11 + 12 . | P value . |
|---|---|---|---|---|---|
| Nonobese | |||||
| n (men/women) | 27/38 | 10/22 | 1/3 | 37/60 | 0.61 (0.87) |
| Age (years) | 36 (30–47) | 37 (33–46) | 32 (28–48) | 36 (31–47) | 0.85 (0.61) |
| BMI (kg/m2) | 23.4 (21.8–24.2) | 23.1 (21.2–24.2) | 23.5 (17.8–24.3) | 23.4 (21.6–24.2) | 0.81 (0.91) |
| Basal lipolysis (μg glycerol · g lipid−1 · 2 h−1) | 0.79 (0.52–1.30) | 0.76 (0.53–1.24) | 1.44 (0.45–1.55) | 0.78 (0.53–1.25) | 0.80 (0.51) |
| [64] | [32] | [3] | [96] | ||
| Isoprenaline | 6.27 (4.52–8.80) | 6.56 (4.26–8.63) | 7.90 (4.37–8.25) | 6.27 (4.41–8.66) | 0.98 (0.82) |
| [63] | [29] | [3] | [92] | ||
| Norepinephrine | 3.19 (2.02–4.65) | 3.25 (2.39–5.96) | 2.81 (2.74–4.74) | 3.25 (2.21–4.92) | 0.73 (0.89) |
| [62] | [32] | [3] | [94] | ||
| Obese | |||||
| n (men/women) | 20/69 | 11/21 | 2/7 | 31/90 | 0.40 (0.82) |
| Age (years) | 39 (28/48) | 37 (30–46) | 47 (25–52) | 38 (29–48) | 0.95 (0.77) |
| BMI (kg/m2) | 40.4 (35.6–44.8) | 38.3 (33.4–41.1) | 35.9 (31.4–40.4) | 39.5 (35.4–43.7) | 0.063 (0.13) |
| Basal lipolysis (μg glycerol · g lipid−1 · 2 h−1) | 1.28 (0.79–1.83) | 1.32 (0.76–1.92) | 0.68 (0.43–0.96) | 1.30 (0.79–1.83) | 0.025 (0.007) |
| [89] | [32] | [9] | [121] | ||
| Isoprenaline | 4.57 (3.13–5.75) | 4.19 (3.15–4.88) | 3.56 (1.80–4.33) | 4.41 (3.13–5.57) | 0.13 (0.055) |
| [88] | [31] | [9] | [119] | ||
| Norepinephrine | 3.08 (2.10–4.06) | 2.77 (2.27–3.86) | 2.57 (1.31–3.09) | 2.90 (2.14–4.00) | 0.30 (0.12) |
| [88] | [32] | [9] | [120] |
| Stimulation . | 11 . | 12 . | 22 . | 11 + 12 . | P value . |
|---|---|---|---|---|---|
| Nonobese | |||||
| n (men/women) | 27/38 | 10/22 | 1/3 | 37/60 | 0.61 (0.87) |
| Age (years) | 36 (30–47) | 37 (33–46) | 32 (28–48) | 36 (31–47) | 0.85 (0.61) |
| BMI (kg/m2) | 23.4 (21.8–24.2) | 23.1 (21.2–24.2) | 23.5 (17.8–24.3) | 23.4 (21.6–24.2) | 0.81 (0.91) |
| Basal lipolysis (μg glycerol · g lipid−1 · 2 h−1) | 0.79 (0.52–1.30) | 0.76 (0.53–1.24) | 1.44 (0.45–1.55) | 0.78 (0.53–1.25) | 0.80 (0.51) |
| [64] | [32] | [3] | [96] | ||
| Isoprenaline | 6.27 (4.52–8.80) | 6.56 (4.26–8.63) | 7.90 (4.37–8.25) | 6.27 (4.41–8.66) | 0.98 (0.82) |
| [63] | [29] | [3] | [92] | ||
| Norepinephrine | 3.19 (2.02–4.65) | 3.25 (2.39–5.96) | 2.81 (2.74–4.74) | 3.25 (2.21–4.92) | 0.73 (0.89) |
| [62] | [32] | [3] | [94] | ||
| Obese | |||||
| n (men/women) | 20/69 | 11/21 | 2/7 | 31/90 | 0.40 (0.82) |
| Age (years) | 39 (28/48) | 37 (30–46) | 47 (25–52) | 38 (29–48) | 0.95 (0.77) |
| BMI (kg/m2) | 40.4 (35.6–44.8) | 38.3 (33.4–41.1) | 35.9 (31.4–40.4) | 39.5 (35.4–43.7) | 0.063 (0.13) |
| Basal lipolysis (μg glycerol · g lipid−1 · 2 h−1) | 1.28 (0.79–1.83) | 1.32 (0.76–1.92) | 0.68 (0.43–0.96) | 1.30 (0.79–1.83) | 0.025 (0.007) |
| [89] | [32] | [9] | [121] | ||
| Isoprenaline | 4.57 (3.13–5.75) | 4.19 (3.15–4.88) | 3.56 (1.80–4.33) | 4.41 (3.13–5.57) | 0.13 (0.055) |
| [88] | [31] | [9] | [119] | ||
| Norepinephrine | 3.08 (2.10–4.06) | 2.77 (2.27–3.86) | 2.57 (1.31–3.09) | 2.90 (2.14–4.00) | 0.30 (0.12) |
| [88] | [32] | [9] | [120] |
Data are presented as median with interquartile range within parenthesis (25th–75th percentile) and number of observations within brackets [n]. The P value within parentheses represents the comparison between the genotypes 11 + 12 and 22. P values are calculated using Kruskal-Wallis or Wilcoxon’s test. 1, major allele; 2, minor allele.