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TABLE 5

Risk estimates (ORs) and 95% CI for haplotype block 1 alleles associated with type 1 diabetes

OR (95% CI)P value (trend test)Cumulative OR (95% CI)
A-T-C-C allele    
    Reference (0 copies) 0.05 1.29 (1.01–1.65) 
    Heterozygote (1 copy) 1.24 (0.95–1.61)   
    Homozygote (2 copies) 1.60 (0.75–3.56)   
    
C-C-T-C allele    
    Reference (0 copies) 0.03 0.78 (0.62–0.97) 
    Heterozygote (1 copy) 0.97 (0.67–1.43)   
    Homozygote (2 copies) 0.73 (0.49–1.08)   
    
OR (95% CI)P value (trend test)Cumulative OR (95% CI)
A-T-C-C allele    
    Reference (0 copies) 0.05 1.29 (1.01–1.65) 
    Heterozygote (1 copy) 1.24 (0.95–1.61)   
    Homozygote (2 copies) 1.60 (0.75–3.56)   
    
C-C-T-C allele    
    Reference (0 copies) 0.03 0.78 (0.62–0.97) 
    Heterozygote (1 copy) 0.97 (0.67–1.43)   
    Homozygote (2 copies) 0.73 (0.49–1.08)   
    

Cumulative OR represents the overall risk associated with an incremental increase in the number of copies of the allele.

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