Insulin sensitivity and secretion in individuals with the D/D and D/N genotypes
| Genotype . | n . | BMI (kg/m2) . | Si × 10−5 min−1/pmol/l . | AIRg (pmol/l) . | Disposition index . | Acute insulin response to tolbutamide (pmol/l) . |
|---|---|---|---|---|---|---|
| D/D | 112 | 27.4 (22.3–33.6) | 6.56 (2.621–6.4) | 175 (83–369) | 0.0114 (0.0032–0.0403) | 487 (229–1034) |
| D/N | 5 | 27.5 (21.6–35.0) | 5.08 (1.81–14.3) | 133 (38–473) | 0.0107 (0.0071–0.0161) | 296 (117–751) |
| Genotype . | n . | BMI (kg/m2) . | Si × 10−5 min−1/pmol/l . | AIRg (pmol/l) . | Disposition index . | Acute insulin response to tolbutamide (pmol/l) . |
|---|---|---|---|---|---|---|
| D/D | 112 | 27.4 (22.3–33.6) | 6.56 (2.621–6.4) | 175 (83–369) | 0.0114 (0.0032–0.0403) | 487 (229–1034) |
| D/N | 5 | 27.5 (21.6–35.0) | 5.08 (1.81–14.3) | 133 (38–473) | 0.0107 (0.0071–0.0161) | 296 (117–751) |
Data are geometric means (95% CI). Characteristics of nondiabetic individuals by genotype at D76N. No differences between D/N carriers and all others with the D/D genotype are significant.